Difference between revisions of "Renal hybrid oncocytic/chromophobe tumour"
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*Rare. | *Rare. | ||
*Molecular heterogeneous group<ref name=pmid23740406/> - may represent several different entities. | *Molecular heterogeneous group<ref name=pmid23740406/> - may represent several different entities. | ||
*Prognosis good - based on one series of 11 cases.<ref name=pmid23708994/> | |||
May be seen in several contexts:<ref name=pmid23740406/> | May be seen in several contexts:<ref name=pmid23740406/> | ||
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*Other [[renal tumours with eosinophilic cytoplasm]]. | *Other [[renal tumours with eosinophilic cytoplasm]]. | ||
*[[Renal cell carcinoma, unclassified]]. | *[[Renal cell carcinoma, unclassified]]. | ||
==Stains== | |||
Features:<ref name=pmid23708994>{{Cite journal | last1 = Poté | first1 = N. | last2 = Vieillefond | first2 = A. | last3 = Couturier | first3 = J. | last4 = Arrufat | first4 = S. | last5 = Metzger | first5 = I. | last6 = Delongchamps | first6 = NB. | last7 = Camparo | first7 = P. | last8 = Mège-Lechevallier | first8 = F. | last9 = Molinié | first9 = V. | title = Hybrid oncocytic/chromophobe renal cell tumours do not display genomic features of chromophobe renal cell carcinomas. | journal = Virchows Arch | volume = 462 | issue = 6 | pages = 633-8 | month = Jun | year = 2013 | doi = 10.1007/s00428-013-1422-4 | PMID = 23708994 }}</ref> | |||
*[[Hale's colloidal iron]] +ve (apical pattern). | |||
==IHC== | ==IHC== | ||
Features: | Features: | ||
*CD117 +ve (practically definitional). | *CD117 +ve (practically definitional<ref name=pmid23740406/>). | ||
*CK7 +ve | *CK7 +ve - may be variable.<ref name=pmid23708994/> | ||
==Molecular== | |||
*No features characteristic of [[chromophobe RCC]] on array-CGH analysis.<ref name=pmid23708994/> | |||
==See also== | ==See also== | ||
| Line 33: | Line 41: | ||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Genitourinary pathology]] | [[Category:Genitourinary pathology]] | ||
[[Category:Diagnosis]] | |||
Revision as of 14:44, 15 June 2015
Renal hybrid oncocytic/chromophobe tumour, also hybrid oncocytic/chromophobe tumour (abbreviated HOCT) and hybrid tumour, is a rare kidney tumour with features of chromophobe renal cell carcinoma and renal oncocytoma.[1]
General
- Rare.
- Molecular heterogeneous group[1] - may represent several different entities.
- Prognosis good - based on one series of 11 cases.[2]
May be seen in several contexts:[1]
- Sporadic.
- Birt–Hogg–Dubé syndrome.
- Renal oncocytosis.
Microscopic
Three morphologic patterns as per Hes et al.:[1]
- Renal oncocytoma and chromophobe renal cell carcinoma collision tumour.
- Different fields viewed in isolation would be compatible with the different diagnoses. Tumour component do not intermingle.
- Renal oncocytoma with scattered chromophobe cells.
- Large eosinophilic cell with intracytoplasmic vacuoles.
DDx:
- Renal oncocytoma - may have limited chromophobe-like areas (<=5% of tumour).[3]
- Chromophobe renal cell carcinoma, eosinophilic variant.
- Other renal tumours with eosinophilic cytoplasm.
- Renal cell carcinoma, unclassified.
Stains
Features:[2]
- Hale's colloidal iron +ve (apical pattern).
IHC
Features:
Molecular
- No features characteristic of chromophobe RCC on array-CGH analysis.[2]
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Hes, O.; Petersson, F.; Kuroda, N.; Hora, M.; Michal, M. (Oct 2013). "Renal hybrid oncocytic/chromophobe tumors - a review.". Histol Histopathol 28 (10): 1257-64. PMID 23740406.
- ↑ 2.0 2.1 2.2 2.3 Poté, N.; Vieillefond, A.; Couturier, J.; Arrufat, S.; Metzger, I.; Delongchamps, NB.; Camparo, P.; Mège-Lechevallier, F. et al. (Jun 2013). "Hybrid oncocytic/chromophobe renal cell tumours do not display genomic features of chromophobe renal cell carcinomas.". Virchows Arch 462 (6): 633-8. doi:10.1007/s00428-013-1422-4. PMID 23708994.
- ↑ Trpkov, K.; Yilmaz, A.; Uzer, D.; Dishongh, KM.; Quick, CM.; Bismar, TA.; Gokden, N. (Dec 2010). "Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features.". Histopathology 57 (6): 893-906. doi:10.1111/j.1365-2559.2010.03726.x. PMID 21166703.