Difference between revisions of "Renal hybrid oncocytic/chromophobe tumour"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Synonyms  =
| Micro      = features of [[renal oncocytoma]] and [[chromophobe renal cell carcinoma]]
| Subtypes  =
| LMDDx      = [[renal oncocytoma]], [[chromophobe renal cell carcinoma]], [[renal cell carcinoma, unclassified]], other [[renal tumours with eosinophilic cytoplasm]]
| Stains    = Hale's colloidal iron +ve
| IHC        = CD117 +ve, CK7 +ve (variable)
| EM        =
| Molecular  = no features of [[ChRCC]]
| IF        =
| Gross      =
| Grossing  =
| Site      = [[kidney]] - see ''[[kidney tumours]]''
| Assdx      =
| Syndromes  = [[Birt–Hogg–Dubé syndrome]]
| Clinicalhx = renal mass
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = good on very limited data
| Other      =
| ClinDDx    =
| Tx        = surgical excision
}}
'''Renal hybrid oncocytic/chromophobe tumour''', also '''hybrid oncocytic/chromophobe tumour''' (abbreviated '''HOCT''') and '''hybrid tumour''', is a rare [[kidney tumour]] with features of [[chromophobe renal cell carcinoma]] and [[renal oncocytoma]].<ref name=pmid23740406>{{Cite journal  | last1 = Hes | first1 = O. | last2 = Petersson | first2 = F. | last3 = Kuroda | first3 = N. | last4 = Hora | first4 = M. | last5 = Michal | first5 = M. | title = Renal hybrid oncocytic/chromophobe tumors - a review. | journal = Histol Histopathol | volume = 28 | issue = 10 | pages = 1257-64 | month = Oct | year = 2013 | doi =  | PMID = 23740406 }}</ref>
'''Renal hybrid oncocytic/chromophobe tumour''', also '''hybrid oncocytic/chromophobe tumour''' (abbreviated '''HOCT''') and '''hybrid tumour''', is a rare [[kidney tumour]] with features of [[chromophobe renal cell carcinoma]] and [[renal oncocytoma]].<ref name=pmid23740406>{{Cite journal  | last1 = Hes | first1 = O. | last2 = Petersson | first2 = F. | last3 = Kuroda | first3 = N. | last4 = Hora | first4 = M. | last5 = Michal | first5 = M. | title = Renal hybrid oncocytic/chromophobe tumors - a review. | journal = Histol Histopathol | volume = 28 | issue = 10 | pages = 1257-64 | month = Oct | year = 2013 | doi =  | PMID = 23740406 }}</ref>


Revision as of 15:26, 15 June 2015

Renal hybrid oncocytic/chromophobe tumour
Diagnosis in short
LM features of renal oncocytoma and chromophobe renal cell carcinoma
LM DDx renal oncocytoma, chromophobe renal cell carcinoma, renal cell carcinoma, unclassified, other renal tumours with eosinophilic cytoplasm
Stains Hale's colloidal iron +ve
IHC CD117 +ve, CK7 +ve (variable)
Molecular no features of ChRCC
Site kidney - see kidney tumours
Syndromes Birt–Hogg–Dubé syndrome
Clinical history renal mass
Prevalence very rare
Prognosis good on very limited data
Treatment surgical excision

Renal hybrid oncocytic/chromophobe tumour, also hybrid oncocytic/chromophobe tumour (abbreviated HOCT) and hybrid tumour, is a rare kidney tumour with features of chromophobe renal cell carcinoma and renal oncocytoma.[1]

General

  • Rare.
  • Molecular heterogeneous group[1] - may represent several different entities.
  • Prognosis good - based on one series of 11 cases.[2]

May be seen in several contexts:[1]

Microscopic

Three morphologic patterns as per Hes et al.:[1]

  1. Renal oncocytoma and chromophobe renal cell carcinoma collision tumour.
    • Different fields viewed in isolation would be compatible with the different diagnoses. Tumour component do not intermingle.
  2. Renal oncocytoma with scattered chromophobe cells.
  3. Large eosinophilic cell with intracytoplasmic vacuoles.

DDx:

Stains

Features:[2]

IHC

Features:

  • CD117 +ve (practically definitional[1]).
  • CK7 +ve - may be variable.[2]

Molecular

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Hes, O.; Petersson, F.; Kuroda, N.; Hora, M.; Michal, M. (Oct 2013). "Renal hybrid oncocytic/chromophobe tumors - a review.". Histol Histopathol 28 (10): 1257-64. PMID 23740406.
  2. ↑ 2.0 2.1 2.2 2.3 Poté, N.; Vieillefond, A.; Couturier, J.; Arrufat, S.; Metzger, I.; Delongchamps, NB.; Camparo, P.; Mège-Lechevallier, F. et al. (Jun 2013). "Hybrid oncocytic/chromophobe renal cell tumours do not display genomic features of chromophobe renal cell carcinomas.". Virchows Arch 462 (6): 633-8. doi:10.1007/s00428-013-1422-4. PMID 23708994.
  3. ↑ Trpkov, K.; Yilmaz, A.; Uzer, D.; Dishongh, KM.; Quick, CM.; Bismar, TA.; Gokden, N. (Dec 2010). "Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features.". Histopathology 57 (6): 893-906. doi:10.1111/j.1365-2559.2010.03726.x. PMID 21166703.
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