Difference between revisions of "In-transit metastasis"
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'''In-transit metastasis''' is a type of metastatic disease, characterized by tumour nodules growing within lymphatics.<ref name=pmid15115646>{{Cite journal | last1 = Fraker | first1 = DL. | title = Management of in-transit melanoma of the extremity with isolated limb perfusion. | journal = Curr Treat Options Oncol | volume = 5 | issue = 3 | pages = 173-84 | month = Jun | year = 2004 | doi = | PMID = 15115646 }}</ref> | '''In-transit metastasis''' is a type of [[metastasis|metastatic disease]], characterized by tumour nodules growing within lymphatics.<ref name=pmid15115646>{{Cite journal | last1 = Fraker | first1 = DL. | title = Management of in-transit melanoma of the extremity with isolated limb perfusion. | journal = Curr Treat Options Oncol | volume = 5 | issue = 3 | pages = 173-84 | month = Jun | year = 2004 | doi = | PMID = 15115646 }}</ref> | ||
It is relatively common in [[malignant melanoma]].<ref name=pmid15115646>{{Cite journal | last1 = Fraker | first1 = DL. | title = Management of in-transit melanoma of the extremity with isolated limb perfusion. | journal = Curr Treat Options Oncol | volume = 5 | issue = 3 | pages = 173-84 | month = Jun | year = 2004 | doi = | PMID = 15115646 }}</ref> It may be seen in a number of tumours, e.g. squamous cell carinoma,<ref name=pmid25775628 >{{Cite journal | last1 = Kocatürk | first1 = E. | last2 = Ülkümen | first2 = PK. | last3 = Kızıltaç | first3 = U. | last4 = Yüksel | first4 = T. | last5 = Kunter | first5 = AS. | last6 = Erhan | first6 = SŞ. | title = In-transit metastasis from primary cutaneous squamous cell carcinoma in a nonimmunosuppressed patient. | journal = J Cutan Med Surg | volume = 19 | issue = 2 | pages = 167-70 | month = | year = | doi = 10.2310/7750.2014.14047 | PMID = 25775628 }}</ref><ref>{{Cite journal | last1 = Altunay | first1 = I. | last2 = Çerman | first2 = AA. | last3 = Sakiz | first3 = D. | last4 = Ates | first4 = B. | title = Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review. | journal = Ann Dermatol | volume = 27 | issue = 4 | pages = 442-5 | month = Aug | year = 2015 | doi = 10.5021/ad.2015.27.4.442 | PMID = 26273163 }}</ref> | It is relatively common in [[malignant melanoma]].<ref name=pmid15115646>{{Cite journal | last1 = Fraker | first1 = DL. | title = Management of in-transit melanoma of the extremity with isolated limb perfusion. | journal = Curr Treat Options Oncol | volume = 5 | issue = 3 | pages = 173-84 | month = Jun | year = 2004 | doi = | PMID = 15115646 }}</ref> It may be seen in a number of tumours, e.g. squamous cell carinoma,<ref name=pmid25775628 >{{Cite journal | last1 = Kocatürk | first1 = E. | last2 = Ülkümen | first2 = PK. | last3 = Kızıltaç | first3 = U. | last4 = Yüksel | first4 = T. | last5 = Kunter | first5 = AS. | last6 = Erhan | first6 = SŞ. | title = In-transit metastasis from primary cutaneous squamous cell carcinoma in a nonimmunosuppressed patient. | journal = J Cutan Med Surg | volume = 19 | issue = 2 | pages = 167-70 | month = | year = | doi = 10.2310/7750.2014.14047 | PMID = 25775628 }}</ref><ref>{{Cite journal | last1 = Altunay | first1 = I. | last2 = Çerman | first2 = AA. | last3 = Sakiz | first3 = D. | last4 = Ates | first4 = B. | title = Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review. | journal = Ann Dermatol | volume = 27 | issue = 4 | pages = 442-5 | month = Aug | year = 2015 | doi = 10.5021/ad.2015.27.4.442 | PMID = 26273163 }}</ref> | ||
Revision as of 14:59, 11 October 2015
In-transit metastasis is a type of metastatic disease, characterized by tumour nodules growing within lymphatics.[1]
It is relatively common in malignant melanoma.[1] It may be seen in a number of tumours, e.g. squamous cell carinoma,[2][3] ecrrine porocarcinoma[4], Merkel cell carcinoma.[5]
General
- May be how a tumour (e.g. melanoma[6]) recurs.
- Poor prognosticator.
Gross
- Often not apparent.
Microscopic
Features:
- Tumour nodule within a lymphatic with or without extension into the surrounding tissue.
DDx:
- Lymph node metastasis - should have lymphoid tissue and capsule.
- Tumour nodules.
See also
References
- ↑ 1.0 1.1 Fraker, DL. (Jun 2004). "Management of in-transit melanoma of the extremity with isolated limb perfusion.". Curr Treat Options Oncol 5 (3): 173-84. PMID 15115646.
- ↑ Kocatürk, E.; Ülkümen, PK.; Kızıltaç, U.; Yüksel, T.; Kunter, AS.; Erhan, SŞ.. "In-transit metastasis from primary cutaneous squamous cell carcinoma in a nonimmunosuppressed patient.". J Cutan Med Surg 19 (2): 167-70. doi:10.2310/7750.2014.14047. PMID 25775628.
- ↑ Altunay, I.; Çerman, AA.; Sakiz, D.; Ates, B. (Aug 2015). "Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review.". Ann Dermatol 27 (4): 442-5. doi:10.5021/ad.2015.27.4.442. PMID 26273163.
- ↑ Imafuku, K.; Hata, H.; Kitamura, S.; Iwata, H.; Shimizu, H. (Jul 2015). "In-transit metastasis of advanced eccrine porocarcinoma.". Int J Dermatol. doi:10.1111/ijd.12928. PMID 26234455.
- ↑ Gunaratne, DA.; Howle, JR.; Veness, MJ. (Mar 2015). "Merkel cell carcinoma: A case of palliative upper limb amputation in a patient with refractory in-transit metastases.". Australas J Dermatol. doi:10.1111/ajd.12291. PMID 25754425.
- ↑ Grotz, TE.; Mansfield, AS.; Kottschade, LA.; Erickson, LA.; Otley, CC.; Markovic, SN.; Jakub, JW. (Dec 2011). "In-transit melanoma: an individualized approach.". Oncology (Williston Park) 25 (14): 1340-8. PMID 22329185.