Difference between revisions of "Acquired cystic disease-associated renal cell carcinoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Synonyms  =
| Micro      = sieve-like architecture (tubular structures/cribriforming), oxylate crystals
| Subtypes  =
| LMDDx      = [[acquired cystic renal disease]], [[papillary renal cell carcinoma]], [[hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]]
| Stains    =
| IHC        = AMACR +ve, CD10 +ve, pankeratin +ve, CK7 +ve (heterogeneous), EMA -ve
| EM        =
| Molecular  =
| IF        =
| Gross      = kidney with cystic changes, thinned cortex
| Grossing  = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]]
| Staging    = [[kidney cancer staging]]
| Site      = [[kidney]] - see [[kidney tumours]]
| Assdx      = [[end-stage renal disease]]
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Acquired cystic disease-associated renal cell carcinoma''', abbreviated '''ACD-RCC''', is a rare [[kidney cancer]] that arises in the context of [[chronic renal failure]].
'''Acquired cystic disease-associated renal cell carcinoma''', abbreviated '''ACD-RCC''', is a rare [[kidney cancer]] that arises in the context of [[chronic renal failure]].


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==Microscopic==
==Microscopic==
Features:
Features:
*Tubular strucutres with cribriforming/a sieve-like architecture.<ref>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}
*Tubular structures with cribriforming/a sieve-like architecture.<ref>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}
</ref>
</ref>
**[[Hobnail]] cells.
**[[Hobnail]] cells.

Revision as of 12:53, 21 April 2016

Acquired cystic disease-associated renal cell carcinoma
Diagnosis in short
LM sieve-like architecture (tubular structures/cribriforming), oxylate crystals
LM DDx acquired cystic renal disease, papillary renal cell carcinoma, hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma
IHC AMACR +ve, CD10 +ve, pankeratin +ve, CK7 +ve (heterogeneous), EMA -ve
Gross kidney with cystic changes, thinned cortex
Grossing notes total nephrectomy for tumour grossing, partial nephrectomy grossing
Staging kidney cancer staging
Site kidney - see kidney tumours
Associated Dx end-stage renal disease
Prevalence rare

Acquired cystic disease-associated renal cell carcinoma, abbreviated ACD-RCC, is a rare kidney cancer that arises in the context of chronic renal failure.

General

Gross

  • Cysts.

Microscopic

Features:

  • Tubular structures with cribriforming/a sieve-like architecture.[2]
  • Oxylate crystals - important.
    • Look somewhat like cholesterol clefts.

DDx:

Images

IHC

Features:[1]

  • AMACR +ve.
  • CD10 +ve.
  • Pankeratin +ve.
  • CK7 +ve (heterogeneous).

Others:[1]

  • CD68 -ve.
  • PAX2 -ve.
  • EMA -ve.[4]
  • HMWCK -ve.[4]
  • Vimentin +ve/-ve.[4]
  • CAM5.2 +ve/-ve.[4]

See also

References

  1. ↑ 1.0 1.1 1.2 Ahn, S.; Kwon, GY.; Cho, YM.; Jun, SY.; Choi, C.; Kim, HJ.; Park, YW.; Park, WS. et al. (Mar 2013). "Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features.". Med Mol Morphol. doi:10.1007/s00795-013-0028-x. PMID 23471757.
  2. ↑ Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.
  3. ↑ 3.0 3.1 URL: https://www.auanet.org/education/modules/pathology/kidney-carcinomas/acquired-cystic.cfm. Accessed on: 13 May 2015.
  4. ↑ 4.0 4.1 4.2 4.3 Amin, Mahul B.; Eble, John; Grignon, David; Srigley, John. (2013). Urological Pathology (1st ed.). Wolters Kluwer. pp. 113. ISBN 978-0781782814.
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