Difference between revisions of "Hepatitis B"
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'''Hepatitis B''' is a relatively common [[medical liver disease]] caused by the ''hepatitis B virus''. | |||
==General== | |||
*May lead to [[hepatocellular carcinoma]] without [[cirrhosis]]. | |||
*High prevalence. | |||
*Diagnosis is by serology. | |||
*A vaccination is available and done routinely in a many jurisdictions.<ref>{{Cite journal | last1 = Leuridan | first1 = E. | last2 = Van Damme | first2 = P. | title = Hepatitis B and the need for a booster dose. | journal = Clin Infect Dis | volume = 53 | issue = 1 | pages = 68-75 | month = Jul | year = 2011 | doi = 10.1093/cid/cir270 | PMID = 21653306 }}</ref> | |||
Associated pathology: | |||
*[[Polyarteritis nodosa]] (PAN). | |||
*[[Membranoproliferative glomerulonephritis]]. | |||
*[[Membranous nephropathy]]. | |||
==Microscopic== | |||
Features: | |||
*Lobular inflammation - this is non-specific finding. | |||
**Hepatocyte necrosis: | |||
***Necrotic hepatocytes look a lot like neutrophils - however: | |||
****Cytoplasm is more pink. | |||
****Round apoptotic bodies. | |||
*[[Ground glass hepatocytes]] - '''important'''. | |||
DDx: | |||
*[[Hepatitis C]]. | |||
*[[Autoimmune hepatitis]]. | |||
*[[Primary biliary cirrhosis]] without [[granulomas]]. | |||
*[[Drug-induced liver disease|Drug reaction]]. | |||
===Image=== | |||
<gallery> | |||
Image:Ground_glass_hepatocytes_high_mag_cropped_2.jpg | GGH - high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
*[[Hepatitis B]] +ve. | |||
==See also== | |||
*[[Medical liver disease]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Medical liver disease]] | |||
Revision as of 17:40, 25 June 2016
Hepatitis B is a relatively common medical liver disease caused by the hepatitis B virus.
General
- May lead to hepatocellular carcinoma without cirrhosis.
- High prevalence.
- Diagnosis is by serology.
- A vaccination is available and done routinely in a many jurisdictions.[1]
Associated pathology:
Microscopic
Features:
- Lobular inflammation - this is non-specific finding.
- Hepatocyte necrosis:
- Necrotic hepatocytes look a lot like neutrophils - however:
- Cytoplasm is more pink.
- Round apoptotic bodies.
- Necrotic hepatocytes look a lot like neutrophils - however:
- Hepatocyte necrosis:
- Ground glass hepatocytes - important.
DDx:
Image
GGH - high mag. (WC)
IHC
- Hepatitis B +ve.
See also
References
- ↑ Leuridan, E.; Van Damme, P. (Jul 2011). "Hepatitis B and the need for a booster dose.". Clin Infect Dis 53 (1): 68-75. doi:10.1093/cid/cir270. PMID 21653306.