Difference between revisions of "Keratins"
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*CK8 ([[CAM5.2]])<ref name=pmid7508102>{{cite journal |author=Murata T, Nakashima Y, Takeuchi M, Sueishi K, Inomata H |title=The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma |journal=Pathol. Res. Pract. |volume=189 |issue=8 |pages=888–93 |year=1993 |month=September |pmid=7508102 |doi= |url=}}</ref> - used to look for mets from breast cancer in axillary lymph nodes. | *CK8 ([[CAM5.2]])<ref name=pmid7508102>{{cite journal |author=Murata T, Nakashima Y, Takeuchi M, Sueishi K, Inomata H |title=The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma |journal=Pathol. Res. Pract. |volume=189 |issue=8 |pages=888–93 |year=1993 |month=September |pmid=7508102 |doi= |url=}}</ref> - used to look for mets from breast cancer in axillary lymph nodes. | ||
*HWMK (e.g. K903<ref>URL: [http://www.aruplab.com/guides/ug/tests/2003978.jsp http://www.aruplab.com/guides/ug/tests/2003978.jsp]. Accessed on: 17 March 2011.</ref>) - [[squamous cell carcinoma]]. | *HWMK (e.g. K903<ref>URL: [http://www.aruplab.com/guides/ug/tests/2003978.jsp http://www.aruplab.com/guides/ug/tests/2003978.jsp]. Accessed on: 17 March 2011.</ref>) - [[squamous cell carcinoma]]. | ||
==Sarcomas and keratins== | |||
*Most sarcomas are cytokeratin negative. | |||
Classic exceptions: | |||
*[[Angiosarcoma]], epithelioid. | |||
*[[Synovial sarcoma]]. | |||
*[[Chordoma]]. | |||
*[[Desmoplastic small round cell tumour]]. | |||
*[[Epithelioid sarcoma]]. | |||
Others: | |||
*[[Leiomyosarcoma]]. | |||
==See also== | ==See also== | ||
Revision as of 03:17, 2 August 2016
Keratins refers to a set of immunostains that mark filaments that are characteristic of epithelial cells and cancer derived from epithelial cells (carcinomas).
Keratin when used in singular may refer to pankeratin.
Classification
Divided by molecular weight:[1]
- Low molecular weight keratins (LMWK): 7, 8/18, 19, 20.
- High molecular weight keratins (HWMK): 4, 10, 13, 14, 17.
Uses
- CK8 (CAM5.2)[2] - used to look for mets from breast cancer in axillary lymph nodes.
- HWMK (e.g. K903[3]) - squamous cell carcinoma.
Sarcomas and keratins
- Most sarcomas are cytokeratin negative.
Classic exceptions:
- Angiosarcoma, epithelioid.
- Synovial sarcoma.
- Chordoma.
- Desmoplastic small round cell tumour.
- Epithelioid sarcoma.
Others:
See also
References
- ↑ http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm
- ↑ Murata T, Nakashima Y, Takeuchi M, Sueishi K, Inomata H (September 1993). "The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma". Pathol. Res. Pract. 189 (8): 888–93. PMID 7508102.
- ↑ URL: http://www.aruplab.com/guides/ug/tests/2003978.jsp. Accessed on: 17 March 2011.