Difference between revisions of "Hyalinizing trabecular tumour"

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#redirect [[Thyroid_gland#Hyalinizing_trabecular_tumour]]
'''Hyalinizing trabecular tumour''', abbreviated '''HTT''', is a rare tumour of the [[thyroid glands]]. It is also known as '''hyalinizing trabecular adenoma'''.


==General==
*Considered by some to be a variant of [[papillary thyroid carcinoma]].<ref name=pmid11117782>{{cite journal |author=Cheung CC, Boerner SL, MacMillan CM, Ramyar L, Asa SL |title=Hyalinizing trabecular tumor of the thyroid: a variant of papillary carcinoma proved by molecular genetics |journal=Am. J. Surg. Pathol. |volume=24 |issue=12 |pages=1622–6 |year=2000 |month=December |pmid=11117782 |doi= |url=}}</ref>
*Behaviour similar to papillary thyroid carcinoma - indolent.
==Microscopic==
Features:
*Trabecular arrangement of cells.
**May have "curved" trabeculae.
*Extracellular space has hyaline material - '''key feature'''.
*Cytoplasm mimics hyaline material in the extracellular space.
DDx:
*[[Papillary thyroid carcinoma]] (if one believes this is a separate entity).
*[[Medullary thyroid carcinoma]] - not trabecular, nuclei not [[PTC]]-like.
*[[Paraganglioma]].<ref>URL: [http://path.upmc.edu/cases/case465/dx.html http://path.upmc.edu/cases/case465/dx.html]. Accessed on: 17 January 2011.</ref>
===Images===
<gallery>
Image: Hyalinized trabecular tumour - low mag.jpg | HHT - low mag. (WC)
Image: Hyalinized trabecular tumour - intermed mag.jpg | HHT - intermed. mag. (WC)
Image: Hyalinized trabecular tumour - high mag.jpg | HHT - high mag. (WC)
Image: Thyroid gland - high mag.jpg | Thyroid gland - high mag. (WC)
Image: Hyalinized trabecular tumour - 2 - intermed mag.jpg | HHT - intermed. mag. (WC)
Image: Hyalinized trabecular tumour - 2 - high mag.jpg | HHT - high mag. (WC)
Image: Hyalinized trabecular tumour - 3 - intermed mag.jpg | HHT - intermed. mag. (WC)
Image: Hyalinized trabecular tumour - 3 - high mag.jpg | HHT - high mag. (WC)
Image: Hyalinized trabecular tumour - 3 - very high mag.jpg | HHT - very high mag. (WC)
</gallery>
www:
*[http://archive.biomedcentral.com/1742-6413/3/17/figure/F2?highres=y HTT (biomedcentral.com)].<ref name=pmid16867191>{{Cite journal  | last1 = Baloch | first1 = ZW. | last2 = Puttaswamy | first2 = K. | last3 = Brose | first3 = M. | last4 = LiVolsi | first4 = VA. | title = Lack of BRAF mutations in hyalinizing trabecular neoplasm. | journal = Cytojournal | volume = 3 | issue =  | pages = 17 | month =  | year = 2006 | doi = 10.1186/1742-6413-3-17 | PMID = 16867191 }}</ref>
*[http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.article-g01.fs.jpg HTT (ispub.com)].<ref>URL: [http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.html http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.html]. Accessed on: 1 January 2012.</ref>
==IHC==
*Thyroglobulin +ve.
*NSE +ve.
*[[Ki-67 membranous pattern]].<ref name=pmid17525638>{{Cite journal  | last1 = Leonardo | first1 = E. | last2 = Volante | first2 = M. | last3 = Barbareschi | first3 = M. | last4 = Cavazza | first4 = A. | last5 = Dei Tos | first5 = AP. | last6 = Bussolati | first6 = G. | last7 = Papotti | first7 = M. | title = Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? | journal = Appl Immunohistochem Mol Morphol | volume = 15 | issue = 2 | pages = 220-3 | month = Jun | year = 2007 | doi = 10.1097/01.pai.0000213122.66096.f0 | PMID = 17525638 }}</ref>
==See also==
*[[Thyroid gland]].
==References==
{{Reflist|2}}
[[Category:Endocrine pathology]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 17:01, 2 July 2017

Hyalinizing trabecular tumour, abbreviated HTT, is a rare tumour of the thyroid glands. It is also known as hyalinizing trabecular adenoma.

General

Microscopic

Features:

  • Trabecular arrangement of cells.
    • May have "curved" trabeculae.
  • Extracellular space has hyaline material - key feature.
  • Cytoplasm mimics hyaline material in the extracellular space.

DDx:

Images

  • HHT - low mag. (WC)

  • HHT - intermed. mag. (WC)

  • HHT - high mag. (WC)

  • Thyroid gland - high mag. (WC)

  • HHT - intermed. mag. (WC)

  • HHT - high mag. (WC)

  • HHT - intermed. mag. (WC)

  • HHT - high mag. (WC)

  • HHT - very high mag. (WC)

www:

IHC

See also

References

  1. ↑ Cheung CC, Boerner SL, MacMillan CM, Ramyar L, Asa SL (December 2000). "Hyalinizing trabecular tumor of the thyroid: a variant of papillary carcinoma proved by molecular genetics". Am. J. Surg. Pathol. 24 (12): 1622–6. PMID 11117782.
  2. ↑ URL: http://path.upmc.edu/cases/case465/dx.html. Accessed on: 17 January 2011.
  3. ↑ Baloch, ZW.; Puttaswamy, K.; Brose, M.; LiVolsi, VA. (2006). "Lack of BRAF mutations in hyalinizing trabecular neoplasm.". Cytojournal 3: 17. doi:10.1186/1742-6413-3-17. PMID 16867191.
  4. ↑ URL: http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.html. Accessed on: 1 January 2012.
  5. ↑ Leonardo, E.; Volante, M.; Barbareschi, M.; Cavazza, A.; Dei Tos, AP.; Bussolati, G.; Papotti, M. (Jun 2007). "Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact?". Appl Immunohistochem Mol Morphol 15 (2): 220-3. doi:10.1097/01.pai.0000213122.66096.f0. PMID 17525638.
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