Difference between revisions of "Malakoplakia"
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==General== | ==General== | ||
*Classically in the [[urinary bladder]]. | *Classically in the [[urinary bladder]]. | ||
**May be | **May be outside of urinary tract.<ref name=pmid17284117>{{Cite journal | last1 = Yousef | first1 = GM. | last2 = Naghibi | first2 = B. | last3 = Hamodat | first3 = MM. | title = Malakoplakia outside the urinary tract. | journal = Arch Pathol Lab Med | volume = 131 | issue = 2 | pages = 297-300 | month = Feb | year = 2007 | doi = 10.1043/1543-2165(2007)131[297:MOTUT]2.0.CO;2 | PMID = 17284117 }}</ref> | ||
==Gross== | ==Gross== | ||
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*[http://granuloma.homestead.com/malakoplakia_bladder_s92-4486e.jpg Malakoplakia (granuloma.homstead.com)]. | *[http://granuloma.homestead.com/malakoplakia_bladder_s92-4486e.jpg Malakoplakia (granuloma.homstead.com)]. | ||
*[http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=13&cat3=342&stype=d Michaelis-Gutmann bodies (gfmer.ch)]. | *[http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=13&cat3=342&stype=d Michaelis-Gutmann bodies (gfmer.ch)]. | ||
==Stains== | |||
*PAS-D +ve.<ref name=pmid17284117/> | |||
==See also== | ==See also== | ||
Revision as of 13:34, 17 August 2011
Malakoplakia is a thingy that typically arises in the bladder.
General
- Classically in the urinary bladder.
- May be outside of urinary tract.[1]
Gross
- Yellow mass.[2]
- May mimic renal cell carcinoma.
Microscopic
Features:[3]
- Basophilic calcified lysosomes (Michaelis-Gutmann bodies) -- key feature.
- May be inside or outside of macrophages - often size of RBC or larger.
- Large foamy macrophages with granular cytoplasm.
- Occasional multinucleated giant cell.
- Lymphocytes.
DDx:
- Xanthogranulomatous process.
- If you cannot find the Michaelis-Gutmann bodies... it is a xanthogranulomatous process, e.g. xanthogranulomatous pyelonephritis, xanthogranulomatous cystitis.
- Granulomatous inflammation.
- Papillary renal cell carcinoma.
Images:
- Michaelis-Gutmann bodies - high mag. cropped (WC).
- Michaelis-Gutmann bodies - high mag. (WC).
- Malakoplakia (pathconsultddx.com)
- Malakoplakia (granuloma.homstead.com).
- Michaelis-Gutmann bodies (gfmer.ch).
Stains
- PAS-D +ve.[1]
See also
References
- ↑ 1.0 1.1 Yousef, GM.; Naghibi, B.; Hamodat, MM. (Feb 2007). "Malakoplakia outside the urinary tract.". Arch Pathol Lab Med 131 (2): 297-300. doi:10.1043/1543-2165(2007)131[297:MOTUT]2.0.CO;2. PMID 17284117.
- ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70719-7. Accessed on: 9 September 2010.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1027. ISBN 0-7216-0187-1.