Craniopharyngioma

Craniopharyngioma is a benign neuropathology tumour. It is subdivided into papillary craniopharyngioma and adamantinomatous craniopharyngioma.

General

Develop from remains of Rathke's pouch or squamous epithelial cell rests.^[1]

Comes in two flavours:^[1]

Adamantinomatous type.
- Adults and children.
Squamous papillary type.
- Adults individuals.^[2]
- Usually solid.

Radiology:^[1]

Calcified - adamantinomatous type only.
Solid & cystic.

Microscopic

Adamantinomatous

Features (adamantinomatous):^[3]

Well-circumscribed (or pseudoinvasive border).
Multicystic.
Small-to-medium sized cells with moderate amount of basophilic cytoplasm.
Bland nuclei (with occ. small nucleoli).
"Wet" keratin - nests of whorled keratin.
Calcifications (non-psammomatous).

Images

Adamantinomatous craniopharyngioma - very low mag. (WC/Nephron)
Adamantinomatous craniopharyngioma - intermed. mag. (WC/Nephron)
Adamantinomatous craniopharyngioma - very high mag. (WC/Nephron)

Papillary

Features (papillary):^[4]

Non-keratinized squamous epithelium (without nuclear atypia).
Fibrovascular cores (required for papillary).

Notes:

+/-Cilia (rare).
+/-Goblet cell-like formations (rare).

Image

Papillary craniopharyngioma - intermed. mag. (WC/Nephron)
Papillary craniopharyngioma - very high mag. (WC/Nephron)

www:

Craniopharyngioma (med.utah.edu).^[5]

References

↑ ^1.0 ^1.1 ^1.2 Garnett, MR.; Puget, S.; Grill, J.; Sainte-Rose, C. (2007). "Craniopharyngioma.". Orphanet J Rare Dis 2: 18. doi:10.1186/1750-1172-2-18. PMID 17425791.
↑ Giangaspero, F.; Burger, PC.; Osborne, DR.; Stein, RB. (Jan 1984). "Suprasellar papillary squamous epithelioma ("papillary craniopharyngioma").". Am J Surg Pathol 8 (1): 57-64. PMID 6696166.
↑ Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 184. ISBN 978-0470519035.
↑ Perry, Arie; Brat, Daniel J. (2010). Practical Surgical Neuropathology: A Diagnostic Approach: A Volume in the Pattern Recognition series (1st ed.). Churchill Livingstone. pp. 406. ISBN 978-0443069826.
↑ URL: http://library.med.utah.edu/WebPath/jpeg4/ENDO115.jpg. Accessed on: 6 December 2010.

[pmid17425791-1] 1.0 ^1.1 ^1.2 Garnett, MR.; Puget, S.; Grill, J.; Sainte-Rose, C. (2007). "Craniopharyngioma.". Orphanet J Rare Dis 2: 18. doi:10.1186/1750-1172-2-18. PMID 17425791.

[pmid6696166-2] Giangaspero, F.; Burger, PC.; Osborne, DR.; Stein, RB. (Jan 1984). "Suprasellar papillary squamous epithelioma ("papillary craniopharyngioma").". Am J Surg Pathol 8 (1): 57-64. PMID 6696166.

[Ref_DCHH184-3] Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 184. ISBN 978-0470519035.

[Ref_PSNP406-4] Perry, Arie; Brat, Daniel J. (2010). Practical Surgical Neuropathology: A Diagnostic Approach: A Volume in the Pattern Recognition series (1st ed.). Churchill Livingstone. pp. 406. ISBN 978-0443069826.

[5] URL: http://library.med.utah.edu/WebPath/jpeg4/ENDO115.jpg. Accessed on: 6 December 2010.

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Craniopharyngioma

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