Provided clinical history
67 year old male, abdo pain + BRBPR
Site
Colon, splenic flexure
Primary image
Low magnification. H&E stain.
Differential diagnosis
Additional tests
More history
Expand More history
|
The colonoscopy shows some blood. No hemorrhoids present. The rectosigmoid is normal. The splenic flexure appears inflamed. Left colon and TI normal. Previously had several low risk polyps on screening colonscopy. Smoker - 40 pack years. Medications: metformin, HCTZ, Altace, ASA, Liptor, allopurinol.
|
Ask a colleague
Expand Ask a colleague
|
The withering crypts are pretty classic. The debris up top is something that one could see in an infection -- but I suspect the guy is a vasculopath... and its only a focal lesion on endoscopy.
|
Stains
ExpandAlcian blue/PAS to Bilirubin |
---|
Alcian blue/PAS | Expand Dr Torres would ask why! |
Alican blue pH 1.0 | Expand Dr Torres would ask why! |
Alcian blue pH 2.5 | Expand Dr Torres would ask why! |
Auramine | Expand Dr Torres would ask why! |
Bielchowsky | Expand Dr Torres would ask why! |
Bilirubin | Expand Dr Torres would ask why! |
|
---|
|
ExpandColloidal iron to Fontana-Masson |
---|
Colloidal iron | Expand Dr Torres would ask why! |
Congo red | Expand Dr Torres would ask why! |
Cresyl violet | Expand Dr Torres would ask why! |
Dieterle | Expand Dr Torres would ask why! |
Diff Quik | Expand Dr Torres would ask why! |
Fontana-Masson | Expand Dr Torres would ask why! |
|
---|
|
ExpandGallyas to Gremelius |
---|
Gallyas | Expand Dr Torres would ask why! |
Giemsa | Expand Dr Torres would ask why! |
GMS | Expand Dr Torres would ask why! |
Gomori's trichrome | Expand Dr Torres would ask why! |
Gram | Expand Dr Torres would ask why! |
Gremelius | Expand Dr Torres would ask why! |
|
---|
|
ExpandJMS to Mucicarmine |
---|
JMS | Expand Dr Torres would ask why! |
Jones | Expand Dr Torres would ask why! |
Kinyoun | Expand Dr Torres would ask why! |
Luxol fast blue | Expand Dr Torres would ask why! |
Masson trichrome | Expand Dr Torres would ask why! |
M-MAS | Expand Dr Torres would ask why! |
Movat | Expand Dr Torres would ask why! |
Mucicarmine | Expand Dr Torres would ask why! |
|
---|
|
ExpandOil red O to Prussian blue |
---|
Oil red O | Expand Dr Torres would ask why! |
Orecein | Expand Dr Torres would ask why! |
PAS | Expand Dr Torres would ask why! |
PASD | Expand Dr Torres would ask why! |
PASF | Expand Dr Torres would ask why! |
PTAH | Expand Dr Torres would ask why! |
Prussian blue | Expand Dr Torres would ask why! |
|
---|
|
ExpandReticulin to Ziehl-Neelsen |
---|
Reticulin | Expand Dr Torres would ask why! |
Sudan black B | Expand Dr Torres would ask why! |
Toluidine blue | Expand Dr Torres would ask why! |
Verhoeff | Expand Dr Torres would ask why! |
Von Kossa | Expand Dr Torres would ask why! |
Warthin-Starry | Expand Dr Torres would ask why! |
Ziehl-Neeslen | Expand Dr Torres would ask why! |
|
---|
|
IHC
ExpandAlpha-1 AT to Cathepsin K |
---|
alpha-1 AT | Expand Dr Torres would ask why! |
ACTH | Expand Dr Torres would ask why! |
AE1/AE1 | Expand Dr Torres would ask why! |
alpha-fetoprotein | Expand Dr Torres would ask why! |
Alk-I | Expand Dr Torres would ask why! |
AMACR | Expand Dr Torres would ask why! |
AR | Expand Dr Torres would ask why! |
ATRX | Expand Dr Torres would ask why! |
Beta2-microglobulin | Expand Dr Torres would ask why! |
B72.3 | Expand Dr Torres would ask why! |
Beta-catenin | Expand Dr Torres would ask why! |
BCL2 | Expand Dr Torres would ask why! |
BCL6 | Expand Dr Torres would ask why! |
BCLxL | Expand Dr Torres would ask why! |
C3 comp | Expand Dr Torres would ask why! |
CA9 | Expand Dr Torres would ask why! |
Calcitonin | Expand Dr Torres would ask why! |
Calponin | Expand Dr Torres would ask why! |
Calretinin | Expand Dr Torres would ask why! |
CAM5.2 | Expand Dr Torres would ask why! |
Cathepsin K | Expand Dr Torres would ask why! |
|
---|
|
ExpandCD10 to Chromogranin |
---|
CD10 | Expand Dr Torres would ask why! |
CD117 | Expand Dr Torres would ask why! |
CD138 | Expand Dr Torres would ask why! |
CD15 | Expand Dr Torres would ask why! |
CD1a | Expand Dr Torres would ask why! |
CD20 | Expand Dr Torres would ask why! |
CD21 | Expand Dr Torres would ask why! |
CD23 | Expand Dr Torres would ask why! |
CD3 | Expand Dr Torres would ask why! |
CD30 | Expand Dr Torres would ask why! |
CD31 | Expand Dr Torres would ask why! |
CD34 | Expand Dr Torres would ask why! |
CD35 | Expand Dr Torres would ask why! |
CD4 | Expand Dr Torres would ask why! |
CD43 | Expand Dr Torres would ask why! |
CD45 (LCA) | Expand Dr Torres would ask why! |
CD5 | Expand Dr Torres would ask why! |
CD56 | Expand Dr Torres would ask why! |
CD57 | Expand Dr Torres would ask why! |
CD68 | Expand Dr Torres would ask why! |
CD7 | Expand Dr Torres would ask why! |
CD79a | Expand Dr Torres would ask why! |
CD8 | Expand Dr Torres would ask why! |
CD99 | Expand Dr Torres would ask why! |
CDX2 | Expand Dr Torres would ask why! |
CEA-m | Expand Dr Torres would ask why! |
Chromogranin | Expand Dr Torres would ask why! |
|
---|
|
ExpandCK17 to Glypican 3 |
---|
CK17 | Expand Dr Torres would ask why! |
CK19 | Expand Dr Torres would ask why! |
CK20 | Expand Dr Torres would ask why! |
CK34betaE12 | Expand Dr Torres would ask why! |
CK5/6 | Expand Dr Torres would ask why! |
CK7 | Expand Dr Torres would ask why! |
CMV | Expand Dr Torres would ask why! |
c-MYC | Expand Dr Torres would ask why! |
Cyclin D1 | Expand Dr Torres would ask why! |
D2-40 | Expand Dr Torres would ask why! |
Desmin | Expand Dr Torres would ask why! |
DOG1 | Expand Dr Torres would ask why! |
EBV | Expand Dr Torres would ask why! |
EMA | Expand Dr Torres would ask why! |
ER and PR | Expand Dr Torres would ask why! |
Factor VIII | Expand Dr Torres would ask why! |
Factor XIIIa | Expand Dr Torres would ask why! |
Fascin | Expand Dr Torres would ask why! |
FH | Expand Dr Torres would ask why! |
FSH | Expand Dr Torres would ask why! |
Gastrin | Expand Dr Torres would ask why! |
GATA3 | Expand Dr Torres would ask why! |
GCDFP-15 (BRST2) | Expand Dr Torres would ask why! |
GFAP | Expand Dr Torres would ask why! |
GH | Expand Dr Torres would ask why! |
Glucagon | Expand Dr Torres would ask why! |
Glypican-3 | Expand Dr Torres would ask why! |
|
---|
|
ExpandHBME-1 to IgM |
---|
HBME-1 | Expand Dr Torres would ask why! |
HBV core | Expand Dr Torres would ask why! |
HBV surface | Expand Dr Torres would ask why! |
H-caldesmon | Expand Dr Torres would ask why! |
HCG | Expand Dr Torres would ask why! |
Helicobacter | Expand Dr Torres would ask why! |
Hepatocyte | Expand Dr Torres would ask why! |
HER2/neu | Expand Dr Torres would ask why! |
HHV-8 | Expand Dr Torres would ask why! |
HMB-45 | Expand Dr Torres would ask why! |
HNF1beta | Expand Dr Torres would ask why! |
HPV | Expand Dr Torres would ask why! |
HSV-I | Expand Dr Torres would ask why! |
HSV-II | Expand Dr Torres would ask why! |
IDH-1 | Expand Dr Torres would ask why! |
Inhibin | Expand Dr Torres would ask why! |
INI1 (BAF47) | Expand Dr Torres would ask why! |
Insulin | Expand Dr Torres would ask why! |
Kappa | Expand Dr Torres would ask why! |
Ki-67 | Expand Dr Torres would ask why! |
Lambda | Expand Dr Torres would ask why! |
Leu 7 | Expand Dr Torres would ask why! |
IgA | Expand Dr Torres would ask why! |
IgG | Expand Dr Torres would ask why! |
IgM | Expand Dr Torres would ask why! |
|
---|
|
ExpandLH to PDGFR |
---|
LH | Expand Dr Torres would ask why! |
LIN28 | Expand Dr Torres would ask why! |
Lysozyme | Expand Dr Torres would ask why! |
mammoglobin | Expand Dr Torres would ask why! |
MAP2 | Expand Dr Torres would ask why! |
MCV | Expand Dr Torres would ask why! |
Melanin A | Expand Dr Torres would ask why! |
MHC class I | Expand Dr Torres would ask why! |
MITF | Expand Dr Torres would ask why! |
MUM1 | Expand Dr Torres would ask why! |
Myeloperoxidase | Expand Dr Torres would ask why! |
MYO D1 | Expand Dr Torres would ask why! |
Myoglobin | Expand Dr Torres would ask why! |
Napsin | Expand Dr Torres would ask why! |
NF | Expand Dr Torres would ask why! |
NKX3.1 | Expand Dr Torres would ask why! |
NSE | Expand Dr Torres would ask why! |
OCT3/4 | Expand Dr Torres would ask why! |
p16 | Expand Dr Torres would ask why! |
P501S | Expand Dr Torres would ask why! |
p53 | Expand Dr Torres would ask why! |
p57 | Expand Dr Torres would ask why! |
p63 | Expand Dr Torres would ask why! |
Pankeratin | Expand Dr Torres would ask why! |
PAX2 | Expand Dr Torres would ask why! |
PAX5 | Expand Dr Torres would ask why! |
PAX8 | Expand Dr Torres would ask why! |
PCNA | Expand Dr Torres would ask why! |
PDGFR | Expand Dr Torres would ask why! |
|
---|
|
ExpandPLAP to WT1 |
---|
PLAP | Expand Dr Torres would ask why! |
PNL-2C | Expand Dr Torres would ask why! |
Prolactin | Expand Dr Torres would ask why! |
PSA | Expand Dr Torres would ask why! |
PSAP | Expand Dr Torres would ask why! |
RCC | Expand Dr Torres would ask why! |
S-100 | Expand Dr Torres would ask why! |
SALL4 | Expand Dr Torres would ask why! |
Smooth muscle actin | Expand Dr Torres would ask why! |
Somatostatin | Expand Dr Torres would ask why! |
STAT6 | Expand Dr Torres would ask why! |
Synaptophysin | Expand Dr Torres would ask why! |
TdT | Expand Dr Torres would ask why! |
TFE3 | Expand Dr Torres would ask why! |
TFEB | Expand Dr Torres would ask why! |
Thyroglobulin | Expand Dr Torres would ask why! |
Toxoplasma | Expand Dr Torres would ask why! |
TSH | Expand Dr Torres would ask why! |
TTF-1 | Expand Dr Torres would ask why! |
Ubiquitin | Expand Dr Torres would ask why! |
UCHL1 (PGP9.5) | Expand Dr Torres would ask why! |
Ulex Europaeus | Expand Dr Torres would ask why! |
Vimentin | Expand Dr Torres would ask why! |
VIP | Expand Dr Torres would ask why! |
VZV | Expand Dr Torres would ask why! |
WT-1 | Expand Dr Torres would ask why! |
|
---|
|
Chromosomal translocations
ExpandTranslocations Chr 1-10 |
---|
t(1;13) PAX7-FKHR | Expand Dr Torres would ask why! |
t(2,13) PAX3-FKHR | Expand Dr Torres would ask why! |
t(8;14) MYC-IGH | Expand Dr Torres would ask why! |
t(9;22) BCR-ABL | Expand Dr Torres would ask why! |
t(9;22) CHN-EWS | Expand Dr Torres would ask why! |
|
---|
|
ExpandTranslocations Chr 11-13 |
---|
t(11;14) CCND1-IGH | Expand Dr Torres would ask why! |
t(11;22) EWS-WT1 | Expand Dr Torres would ask why! |
t(11;22) FLI1-EWS | Expand Dr Torres would ask why! |
t(12;15) ETV6-NTRK3 | Expand Dr Torres would ask why! |
t(12;16) FUS-ATF1 | Expand Dr Torres would ask why! |
t(12;16) CHOP-TLS | Expand Dr Torres would ask why! |
t(12;22) EWS-ATF1 | Expand Dr Torres would ask why! |
|
---|
|
ExpandTranslocations Chr 14-22 |
---|
t(14,18) IGH-BCL2 | Expand Dr Torres would ask why! |
t(15;17) PML-RARA | Expand Dr Torres would ask why! |
t(16;21) FUS-ERG | Expand Dr Torres would ask why! |
t(17;22) COLA1-PDGFB | Expand Dr Torres would ask why! |
t(21;22) EWS-ERG | Expand Dr Torres would ask why! |
|
---|
|
ExpandTranslocations Chr X & Y |
---|
t(X;1) PRCC-TFE3 | Expand Dr Torres would ask why! |
t(X;17) TFE3-ASPL | Expand Dr Torres would ask why! |
t(X;18) SYT-SSX | Expand Dr Torres would ask why! |
|
---|
|
Diagnosis
Other cases
|
---|
| Number | |
---|
| Subspecialty (Difficulty) |
Autopsy pathology (jr,sr, f/e)
Breast pathology (jr,sr, f/e)
Cardiovascular pathology (jr,sr, f/e)
Cytopathology (jr,sr, f/e)
Dermatopathology (jr,sr, f/e)
Endocrine pathology (jr,sr, f/e)
Forensic pathology (jr,sr, f/e)
Gastrointestinal pathology (jr,sr, f/e)
Genitourinary pathology (jr,sr, f/e)
Gynecologic pathology (jr,sr, f/e)
Hematopathology (jr,sr, f/e)
Head and neck pathology (jr,sr, f/e)
Lymph node pathology (jr,sr, f/e)
Medical kidney pathology (jr,sr, f/e)
Molecular pathology (jr,sr, f/e)
Neuropathology (jr,sr, f/e)
Pediatric pathology (jr,sr, f/e)
Pulmonary pathology (jr,sr, f/e)
Placental pathology (jr,sr, f/e)
Soft tissue pathology (jr,sr, f/e) |
---|
| Difficulty | |
---|
|