Solid pseudopapillary tumour

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Solid pseudopapillary tumour
Diagnosis in short

Solid pseudopapillary tumour. H&E stain.

Synonyms solid pseudopapillary neoplasm, solid and papillary epithelial neoplasm

LM solid sheets of cells - focally dyscohesive, eosinophilic cytoplasm (occasionally clear), focal eosinophilic (intracytoplasmic) globules, uniform nuclei with occasional nuclear grooves, +/-necrosis (creating spaces/cavities), +/-cholesterol clefts
LM DDx pancreatic pseudocyst, cystadenoma, cystadenocarcinoma (see invasive ductal carcinoma of the pancreas), pancreatic neuroendocrine tumour
IHC PR +ve, CD10 +ve, beta-catenin +ve, chromogranin -ve, synaptophysin +ve (weak)
Site pancreas - usually tail

Clinical history typical young (20s or 30s), women (M:F = 1:9)
Prevalence uncommon
Prognosis usu. benign

Solid pseudopapillary tumour is a pancreatic tumour that is usually found in the tail.

It is also known as solid pseudopapillary neoplasm (abbreviation SPN) and solid and papillary epithelial neoplasm (abbreviated SPEN).[1]

General

  • Obscure cell of origin.
  • Considered low grade, i.e. prognosis is usually good.

Epidemiology

Features:[2]

  • Usually females (M:F=1:9).
  • Mean age of presentation third decade (20s).

Management

May be followed radiologically.

Microscopic

Features:[3]

  • Solid sheets of cells, focally dyscohesive.
  • Eosinophilic cytoplasm.
    • Occasionally clear cytoplasm.[4]
    • Focal eosinophilic (intracytoplasmic) globules - key feature.
  • Uniform nuclei with occasional nuclear grooves.
  • +/-Necrosis - creating spaces/cavities.
  • +/-Cholesterol clefts.[5]

DDx:

Images

www:

IHC

Features:[4]

  • Beta-catenin +ve ~100% (cytoplasmic & nuclear).
  • E-cadherin +ve ~100% (cytoplasmic), -ve (membrane); antibody dependent.
  • CD10 +ve ~ 80% (cytoplasmic + dot-like) key.
  • Synaptophysin +ve (weak cytoplasmic) ~70%.
  • Progesterone receptor +ve (nuclear) key.

Others:

  • CD56 +ve.
  • Chromogranin -ve.

Memory device PCB: PR (nuclear), CD10 (cytoplasmic), beta-catenin (cytoplasmic & nuclear).

See also

References

  1. URL: http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html. Accessed on: 31 October 2011.
  2. Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 493. ISBN 978-0443066573.
  3. Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 493-5. ISBN 978-0443066573.
  4. 4.0 4.1 4.2 Serra S, Chetty R (November 2008). "Revision 2: an immunohistochemical approach and evaluation of solid pseudopapillary tumour of the pancreas". J. Clin. Pathol. 61 (11): 1153–9. doi:10.1136/jcp.2008.057828. PMID 18708424. http://jcp.bmj.com/content/61/11/1153.
  5. Abad Licham, M.; Sanchez Lihon, J.; Celis Zapata, J.. "[Pseudopapillary solid tumor of pancreas in the INEN].". Rev Gastroenterol Peru 28 (4): 356-61. PMID 19156179.