Cytokeratin 7
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CK7 immunostain in urothelial carcinoma. (WC)
Cytokeratin 7, also keratin 7 and CK7, is a common low molecular keratin and a very common immunostain.[1]
Positive
Classic positive
- Ovary.
- Breast.
- Endometrium.
- Salivary gland.
- Lung (adenocarcinoma).
- Thyroid gland.
- Mesothelium.
- Pancreas.
- Stomach.
- Urothelial carcinoma.
- Esophageal adenocarcinoma.
Images
Adenocarcinoma of the lung. (WC/Yale Rosen)
CK7 immunostain in acinar adenocarcinoma of the lung. (WC)
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Negative
Classic negative
- Kidney[1] (clear cell renal cell carcinoma). †
- Colon and rectum.[1]
- Prostate.[1]
- Thymus.[1]
- Squamous cell carcinoma. ‡
Notes:
- † Most other common types are CK7 +ve (papillary RCC, chromophobe RCC, clear cell papillary RCC)
- ‡ May be positive. In one series of head and neck SCC, conventional SCC: 7 +ve of 34 cases; basaloid squamous cell carcinoma: 24 +ve of 45 cases.[2]
Images
Entrapped CK7-positive lung parenchyma within a lymphoma. (WC)
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Chu, P.; Wu, E.; Weiss, LM. (Sep 2000). "Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases.". Mod Pathol 13 (9): 962-72. doi:10.1038/modpathol.3880175. PMID 11007036.
- ↑ Winters, R.; Naud, S.; Evans, MF.; Trotman, W.; Kasznica, P.; Elhosseiny, A. (Dec 2008). "Ber-EP4, CK1, CK7 and CK14 are useful markers for basaloid squamous carcinoma: a study of 45 cases.". Head Neck Pathol 2 (4): 265-71. doi:10.1007/s12105-008-0089-7. PMID 20614292.