Exaggerated placental site

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Exaggerated placental site, abbreviated EPS, is an uncommon benign pathology that is a gestational trophoblastic disease.

It was previously known as syncytial endometritis.[1]

General

  • Benign.

Definition:

Note:

  • Used to go by a terrible old term: syncytial endometritis:[2]
    • Not syncytial -- mostly.
    • Not inflammatory.

Microscopic

Features:[2]

  • Intermediate trophoblast:
    • Abundant (eosinophilic) cytoplasm.
  • Usu. adjacent to:
    • Chorionic villi.
    • Decidua - endometrial stromal cells with a nucleus central, eosinphilic cytoplasm, well-defined cell borders.
  • No mitotic activity.
  • Ectatic blood vessels.

DDx:

IHC

  • MIB1 ~0%.
    • Used to differentiate from PSTT.

See also

References

  1. ↑ URL: http://www.webpathology.com/image.asp?case=565&n=7. Accessed on: 22 May 2014.
  2. ↑ 2.0 2.1 URL: http://moon.ouhsc.edu/kfung/IACP-OLP/TC-Text/TC-01-Supp.pdf. Accessed on: 15 August 2011.
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