Tumour regression

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Tumour regression can occur as a consequence of treatment or sporadically.

Sporadic tumour regression

Well-known:

Microscopic

Features:

  • +/-Fibrosis.
  • +/-Mucin.
  • +/-Inflammation.

Grading of tumour regression

There is a three tiered regression grading system by Ryan et al..[2]

References

  1. Balzer, BL.; Ulbright, TM. (Jul 2006). "Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases.". Am J Surg Pathol 30 (7): 858-65. doi:10.1097/01.pas.0000209831.24230.56. PMID 16819328.
  2. Ryan, R.; Gibbons, D.; Hyland, JM.; Treanor, D.; White, A.; Mulcahy, HE.; O'Donoghue, DP.; Moriarty, M. et al. (Aug 2005). "Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer.". Histopathology 47 (2): 141-6. doi:10.1111/j.1365-2559.2005.02176.x. PMID 16045774.