Serous cystadenoma of the pancreas
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Serous cystadenoma of the pancreas is a benign cystic lesion of the pancreas. It may be seen in von Hippel-Lindau disease.
It is also known as serous microcystic adenoma,[1] and pancreatic serous cystadenoma.
General
- 1-2% of all exocrine pancreatic tumours.
- Female > male.
- Mean age 66 years.
- Truly benign with no malignant potenial.
- May be part of von Hippel-Lindau syndrome.
Management:
- Observe or resect.
Gross
Features:
- Classically has a characteristic central scar.[2]
- Bosulated surface.
- Lobulated.
- No (macroscopic) cysts apparent on gross.
- Location: 50-70% occur in the body and tail.
- Size: average size 11 cm.
Radiologic appearance:
- Honey comb-like appearance.
- Well demarcated border - may be described as a "coin lesion".
Image:
Microscopic
Features:
- Cystic spaces lined by cuboidal cells.
- Glycogen rich.
- Cilia. (???)
DDx:
- Renal cell carcinoma.
- Lymphangioma.
- Hemangioma.
- Oligocystic mucinous cystic tumors and pseudocysts.
- Have mucin; PAS-D could be used to demonstrate its presence.
Notes:
- Serous adenoma may coexist with aggressive tumours.
Images
PSC - low mag. (WC)
PSC - intermed. mag. (WC)
PSC - high mag. (WC)
PSC - very high mag. (WC)
Stains
- PAS +ve.
- PASD -ve.
See also
References
- ↑ Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 1630. ISBN 978-0781740517.
- ↑ Kim YH, Saini S, Sahani D, Hahn PF, Mueller PR, Auh YH (2005). "Imaging diagnosis of cystic pancreatic lesions: pseudocyst versus nonpseudocyst". Radiographics 25 (3): 671–85. doi:10.1148/rg.253045104. PMID 15888617. http://radiographics.rsna.org/content/25/3/671.abstract.
- ↑ Vernadakis, S.; Kaiser, GM.; Christodoulou, E.; Mathe, Z.; Troullinakis, M.; Bankfalvi, A.; Paul, A. (2009). "Enormous serous microcystic adenoma of the pancreas.". JOP 10 (3): 332-4. PMID 19454830.