Brenner tumour

The Brenner tumour, abbreviated BT, is an ovarian tumour in the epithelial group of ovarian tumours.

General

• Considered to be rare.
• Traditionally, BT has been grouped within the transistional cell tumours category in the surface epithelial group of ovarian tumours.
  • Recently, transistional cell carcinoma of the ovary has been related to serous carcinoma; TCC of the ovary is probably distinct from the malignant Brenner tumour.

Epidemiology

• Mostly benign clinical course.
• Thought to arise from Walthard cell rest.
• Frequently an incidental finding, i.e. oophorectomy was done for another reason.
• May be malignant.

Gross

Features:

• Classically solid, well-circumscribed, light yellow.
• May be cystic.

Note:

• Borderline tumours classically solid and cystic with papillary projections into the cystic component.

Microscopic

Features:

• Nests of transitional epithelium with cells that have:
  • A "coffee bean nucleus".
    • Elliptical shape (nucleus).
    • Nuclear grooves.
    • Distinct nucleoli.
  • Moderate-to-abundant gray/pale cytoplasm.
• Dense fibrous stroma around nests.

Notes:

• Main DDx of Coffee bean nucleus = granulosa cell tumour.
• Stromal component may be predominant.

DDx:

• Ovarian fibroma.
• Thecoma.

Images

• 

  BT - cropped - high mag. (WC)

• 

  BT - high mag. (WC)

• 

  BT - intermed. mag. (WC)

IHC

Features:

• AR +ve.
• Calretinin -ve.
  • Surrounding stroma +ve.

See also

• Ovarian tumours.