Kidney cytopathology

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Kidney cytopathology is uncommonly done.

Angiomyolipoma

Main article: Angiomyolipoma

General

Cytology

Features:

  • Blood vessels.
  • Fat - usu. scant.
  • Muscle - ovoid, bent cigar-shaped nuclei.

Renal oncocytoma

Main article: Renal oncocytoma

Cytology

Features:[1]

  • Moderate granular cytoplasm.
  • Distinct cell borders.
  • Round nuclei.

Oncocytoma vs chromophobe RCC:[1]

  • ChRCC:
    • Thicker cell borders.
    • Perinuclear clearing/quasi koilocytic appearance.

Image:

Clear cell renal cell carcinoma

Main article: Clear cell renal cell carcinoma

Cytology

Features - classically:

  • Prominent nucleoli.
  • Abundant vacuolated, delicate cytoplasm.
  • Small blood vessels (chicken-wire vasculature).

Note:

  • Cytoplasm not clear.

DDx:

Images:

Chromophobe renal cell carcinoma

Main article: Chromophobe renal cell carcinoma

Cytology

Features:

  • Thick appearing cell membrane - vegetable matter-like appearance.

Papillary renal cell carcinoma

Main article: Papillary renal cell carcinoma

Cytology

Features:

  • Papillary structures - typically have a smooth contour.
    • Contain foamy macrophages.
  • Tumour cells have small nucleoli +/- nuclear grooves.
  • +/-Psammoma bodies.

See also

  1. ↑ 1.0 1.1 Lefkowitch, Jay H. (2006). Anatomic Pathology Board Review (1st ed.). Saunders. pp. 683. ISBN 978-1416025887.
  2. ↑ 2.0 2.1 URL: http://moon.ouhsc.edu/kfung/jty1/CytoLearn/CytoQuiz/CQ-021-040/CQ-025-M.htm. Accessed on: 9 April 2012.
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