Mesonephric remnant of the prostate gland
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Mesonephric remnant of the prostate gland, also mesonephric remnant, is rare benign finding in the prostate gland that can be confused with prostate carcinoma.
This article also deals with mesonephric remnant hyperplasia.
General
- Very rare[1] ~ 0.6% incidence in a series of almost 700 TURP specimens.[2]
- Can mimic prostate carcinoma.[3]
Microscopic
Features:[1]
- Small glands in a lobular arrangement composed of cuboidal cells with:
- Scant-to-moderate cytoplasm.[2]
- Small/indistinct nucleoli.
Note:
- May look like Gleason pattern 3 adenocarcinoma.
DDx:[1]
- Sclerosing adenosis of the prostate gland.
- Prostate carcinoma - esp. Gleason pattern 5.
Images
www:
IHC
Features:[1]
- PAX8 +ve.
- PSA -ve (all).
- PSAP -ve.[2]
- CK34betaE12 +ve/-ve (diffuse +ve in 4/7 cases)
- p63 -ve.
- AMACR +ve (focal).
See also
References
- ↑ 1.0 1.1 1.2 1.3 Chen, YB.; Fine, SW.; Epstein, JI. (Jul 2011). "Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy.". Am J Surg Pathol 35 (7): 1054-61. doi:10.1097/PAS.0b013e318218df97. PMID 21606823.
- ↑ 2.0 2.1 2.2 2.3 Bostwick, DG.; Qian, J.; Ma, J.; Muir, TE. (Jul 2003). "Mesonephric remnants of the prostate: incidence and histologic spectrum.". Mod Pathol 16 (7): 630-5. doi:10.1097/01.MP.0000074733.10777.78. PMID 12861057. Cite error: Invalid
<ref>tag; name "pmid12861057" defined multiple times with different content - ↑ Yacoub, M.; Milin, S.; Irani, J.; Fromont, G. (Dec 2009). "Mesonephric remnant hyperplasia: an unusual benign mimicker of prostate cancer.". Ann Diagn Pathol 13 (6): 402-4. doi:10.1016/j.anndiagpath.2009.03.008. PMID 19917478.