Myeloproliferative neoplasms

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Myeloproliferative neoplasms, also myeloproliferative disorders, are a group of indolent hematologic neoplasms.

These should not be confused with myelodysplastic syndromes (MDS).

Grouping

They include the following:[1]

  • Polycythemia vera.
  • Essential thrombocythemia.
  • Idiopathic myelofibrosis.

Molecular

A specific JAK2 mutation (Val617Phe) in seen in a group of patients.[1][2]

See also

References

  1. ↑ 1.0 1.1 Baxter EJ, Scott LM, Campbell PJ, et al. (2005). "Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders". Lancet 365 (9464): 1054–61. doi:10.1016/S0140-6736(05)71142-9. PMID 15781101.
  2. ↑ Steensma DP, Dewald GW, Lasho TL, et al. (August 2005). "The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes". Blood 106 (4): 1207–9. doi:10.1182/blood-2005-03-1183. PMC 1895198. PMID 15860661. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895198/.
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