Kimura disease

Kimura disease is a rare disease with abundant eosinophils. It may show-up in a lymph node specimen.

General

• AKA eosinophilic lymphogranuloma, Kimura disease.
• Chronic inflammatory disorder - suspected to be infectious.

Clinical:

• Usually neck, periauricular.
• Peripheral blood eosinophilia.
• Increased blood IgE.

Epidemiology

• Males > females.
• Young.
• Asian.

Microscopic

Features:

• Angiolymphoid proliferation.
  • Thick walled blood vessels with (plump) hobnail endothelial cells.
• Eosinophils - abundant - key feature.

DDx:

• Drug reaction.
• Parasitic infection.

Notes:

• In a lymph node... it may be signed-out as reactive lymphadenitis with follicular hyperplasia and prominent eosinophils, see comment.
• Abundant eosinophils: consider Langerhans cell histiocytosis.

Images:

• Kimura disease - very high mag. (WC).
• Kimura disease - high mag. (WC).
• Kimura disease - intermed. mag. (WC).

IHC

• Used to rule-out a clonal population, i.e. lymphoma.

See also

• Lymph node pathology.
• Lymph node.