Histiocytoses

Histiocytoses, singular histiocytosis, are a rare set of conditions affecting tissue macrophages.

Histiocytoses in a table

Features of histiocytoses:

	Histologic features	EM features	CD68	S-100	CD1a	Image
Macrophage	epithelioid cells, giant cells	-	+	-	-	Macrophages - CD68 (WC)
Erdheim-Chester disease	Touton giant cells	-	+	+/-	-
Rosai-Dorfman	Emperipolesis	-	+	+	-	RDD (WC)
Langerhans-histiocytosis	Reniform nuclei, eosinophilic cytoplasm	Birbeck granules	+	+	+	LCH (WC)

Notes:

• EM = electron microscopy.

See also

• Lymph node pathology.
• Neuropathology.
• Hemophagocytic syndrome.