Gonadoblastoma

Gonadoblastoma
Diagnosis in short
Gondaloblastoma. H&E stain.
LM	immature germ cells (resembling Sertoli cells or granulosa cells),[citation needed] primitive germ cells resemble those of a dysgerminoma, +/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells.
LM DDx	dysgerminoma
Site	ovary

Gonadoblastoma is a rare germ cell tumour with sex cord elements.

General

• Associated with abnormal sexual development.
• Often coexist with a dysgerminoma.
• A mixed tumour that consists of (1) primitive germ cells and (2) sex cord elements.

Gross

• +/-Cystic.

Microscopic

Features:

• Immature germ cells resembling Sertoli cells or granulosa cells.^{[citation needed]}
  • Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture.
  • Granulosa cells = form follicle-like structures.
    • May form nests.
• Primitive germ cells resemble those of a dysgerminoma.
  • Polygonal cells with a central nucleus, squared-off nuclear membrane and clear cytoplasm.
• +/-Calcification (very common).
• +/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.

Images

• 

  Gonadoblastoma - intermed. mag. (WC/Nephron)

• 

  Gonadoblastoma - high mag. (WC/Nephron)

www:

• Gonadoblastoma - low mag. (webpathology.com).
• Gonadoblastoma - high mag. (webpathology.com).
• Gonadoblastoma - high mag. (webpathology.com).
• Gonadoblastoma - low mag. (flickr.com).
• Gonadoblastoma - intermed. mag. (flickr.com).
• Gonadoblastoma - high mag. (flickr.com).
• Gonadoblastoma - several cases (upmc.edu).

See also

• Germ cell tumours.