Adamantinoma
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| Adamantinoma | |
|---|---|
| Diagnosis in short | |
 Adamantinoma. H&E stain. | |
| Site | bone - usu. tibia or fibula. |
|
| |
| Prevalence | uncommon |
| Prognosis | benign +/-locally aggressive |
| Clin. DDx | osteosarcoma |
Adamantinoma is an uncommon benign bone tumour. It should not be confused with adenomatoid tumour.
General
Features:[1]
- Rare: < 1% of bone tumours.
- 25-35 years old.
- Benign, may be locally aggressive.
- Cousin of ameloblastoma. (???)
Gross
- Tibia or fibula.
Radiology
- Intracortical, radiolucent.
Microscopic
Features:
- Biphasic tumour:
- Fibrous/spindle cell component.
- Epithelial component.
DDx:[2]
- Vascular tumours (Epithelioid hemangioendothelioma).
- Metastatic carcinoma.
Images
Adamantinoma - intermed. mag. (WC)
www:
IHC
Features:[2]
- CK14 +ve (HMWK).[4]
- CK19 +ve (LMWK).
- CK8/18 -ve (LMWK).
See also
References
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 650. ISBN 978-0781765275.
- ↑ 2.0 2.1 URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2. Accessed on: 28 April 2011.
- ↑ URL: http://southbaypath.org/CaseImages/sb5260/sb5260.htm. Accessed on: 7 December 2010.
- ↑ URL: http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm. Accessed on: 28 April 2011.