Tubular carcinoma of the breast
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Tubular carcinoma of the breast is an uncommon for of invasive breast cancer that at first glance may look like benign breast tissue.
- AKA tubular carcinoma.
General
Epidemiology:
- Typically excellent prognosis.
- Hormone receptors commonly present (ER +ve, PR +ve).
- Usually HER2 -ve.
- Classically seen in post-menopausal women.
Note:
- May be seen in association with lobular carcinoma in situ and columnar cell lesions - known as Rosen triad.[1]
- Memory device TLC = Tubular ca., LCIS, Columnar cell lesions.
Microscopic
- Well-formed tubules.
- Typically have angled ducts - "prows" - important feature (low power).
- Myoepithelial cells absent - diagnostic - may be have to appreciated without IHC.
- >70% of the tumour cells should be adjacent to lumen.[5]
- +/- Cribriform spaces.
- Apocrine snouts typical.
- +/-Calcification.
Notes:
- Prow = front of a ship.
- Looks benign to the uninitiated -- important.
DDx:
Images
www:
IHC
- ER +ve.
- PR +ve.
- HER2 -ve.
- HER2 positivity should prompt consideration of another diagnosis!
See also
References
- ↑ Brandt, SM.; Young, GQ.; Hoda, SA. (May 2008). "The "Rosen Triad": tubular carcinoma, lobular carcinoma in situ, and columnar cell lesions.". Adv Anat Pathol 15 (3): 140-6. doi:10.1097/PAP.0b013e31816ff313. PMID 18434766.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1146. ISBN 0-7216-0187-1.
- ↑ URL: http://www.bweems.com/nsj3mp2.jpg.
- ↑ URL: http://surgpathcriteria.stanford.edu/breast/tubularcabr/.
- ↑ Stalsberg, H.; Hartmann, WH. (May 2000). "The delimitation of tubular carcinoma of the breast.". Hum Pathol 31 (5): 601-7. PMID 10836300.
