Lhermitte-Duclos disease

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Lhermitte-Duclos disease, abbreviated LDD, is a rare neuropathology.

It is also known as dysplastic cerebellar gangliocytoma[1] and dysplastic gangliocytoma of the cerebellum.

General

Microscopic

Features:[3]

  • The outer (molecular) layer has increased cellularity.
  • Purkinje cells absent.[1]
  • Large (polygonal) cells with round nuclei and prominent nucleoli in the inner (granular) layer - key feature.
  • +/-Microcalcifications.

Images

  • LDD. (WC/Jensflorian)

www:

See also

References

  1. ↑ 1.0 1.1 Yağci-Küpeli, B.; Oguz, KK.; Bilen, MA.; Yalçin, B.; Akalan, N.; Büyükpamukçu, M. (Mar 2010). "An unusual cause of posterior fossa mass: Lhermitte-Duclos disease.". J Neurol Sci 290 (1-2): 138-41. doi:10.1016/j.jns.2009.12.010. PMID 20060133.
  2. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 158350
  3. ↑ URL: http://path.upmc.edu/cases/case472.html. Accessed on: 21 January 2012.
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