Mast cell
The mast cell is an uncommonly cell that occasionally causes problems.
Microscopic
Features:
- Ovoid/round cell with moderate amount of gray granular cytoplasm.
- Nuclear ovoid/round.
- No obvious nucleolus.
- May be more abundant around blood vessels.
Notes:
- Lymphocyte vs. mast cell:
- Lymphocytes = round; mast cells = ovoid.
Images
www:
- Mastocytosis - low res. (jameswpattersonmd.com).
- Mastocytosis - bone marrow - several images (upmc.edu).
Mastocytosis - high mag. (WC)
Mastocytosis - very high mag. (WC)
Diseases
- Mastocytosis.
- Urticaria pigmentosa.
- Asthma.[1]
Conditions associated with the presence of mast cells
Stains
- Giemsa stain.
- Tyrosinase.[3] (???)
IHC
- CD117 +ve.
- CD34 +ve.[4][citation needed]
References
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 370-2. ISBN 978-1416054542.
- ↑ Carr, NJ.; Warren, AY. (Jan 1993). "Mast cell numbers in melanocytic naevi and cutaneous neurofibromas.". J Clin Pathol 46 (1): 86-7. PMID 8432898.
- ↑ URL: http://www.nature.com/jid/journal/v53/n1/full/jid1969105a.html. Accessed on: 20 December 2011.
- ↑ Duşe, AO.; Ceauşu, RA.; Mezei, T.; Cîmpean, AM.; Gaje, P.; Ioniţă, H.; Jung, I. (2011). "Mast cells contribute to the angiogenesis in non-Hodgkin lymphoma. An immunohistochemical study based on the relationship with microvessel density.". Rom J Morphol Embryol 52 (3 Suppl): 1091-6. PMID 22119830.