Cushing syndrome
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Cushing syndrome, also hypercortisolism, is when there is too much glucocorticoids.
Clinical
The features can be remembered with CUSHING:[1]
- Central obesity + Cervical fat pad + Comedones (acne).
- Unusual brUising.
- Striae.
- Hypertension + Hyperglycemia.
- Immunosuppression.
- Neoplasia may cause it.
- Growth retardation.
A shorter version is CUSH:
- Central obesity with peripheral wasting, Cervical fat pad.
- Unusual brUising.
- Straiae on Skin.
- Hypertension + Hyperglycemia.
Microscopic
Features - pituitary gland:
- Crooke-hyaline change:[2]
- ACTH producing cell: basophilic granular cytoplasm becomes pale and homogenous.
Crooke´s cell adenoma showing various Crooke cells with hyalinzed cytoplasms. (WC/marvin101)
Ringlike perinuclear expression of cytokeratins in Crooke´s cell adenoma. (WC/marvin101)
See also
References
- ↑ URL: http://www.usmletomd.com/smartmd/2007/09/remembering-clinical-features-of.html. Accessed on: 1 May 2012.
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 581. ISBN 978-1416054542.