STAT6
| STAT6 | |
|---|---|
| Immunostain in short | |
 STAT6+ve in Hemangiopericytoma. | |
| Normal staining pattern | cytoplasmic staining (nuclear is diagnostic) |
| Positive | Hemangiopericytoma, SFT |
| Negative | any healthy tissue |
Signal transducer and activator of transcription 6, commonly abbreviated STAT6 is a diagnostic immunostain, because nuclear staining is found in some specific types of cancer that carry a NAB2-STAT6 fusion [1] or have a STAT6 amplification.[2]
Cytoplasmic STAT6 staining is seen in a wide variety of tissue and represents normal protein localization.
Positive
- Hemangiopericytoma.
- Solitary fibrous tumour.[3]
- well-differentiated/dedifferentiated liposarcoma.[4]
See also
References
- ↑ Schweizer, L.; Koelsche, C.; Sahm, F.; Piro, RM.; Capper, D.; Reuss, DE.; Pusch, S.; Habel, A. et al. (May 2013). "Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein.". Acta Neuropathol 125 (5): 651-8. doi:10.1007/s00401-013-1117-6. PMID 23575898.
- ↑ Doyle, LA.; Tao, D.; Mariño-Enríquez, A. (Sep 2014). "STAT6 is amplified in a subset of dedifferentiated liposarcoma.". Mod Pathol 27 (9): 1231-7. doi:10.1038/modpathol.2013.247. PMID 24457460.
- ↑ Cheah, AL.; Billings, SD.; Goldblum, JR.; Carver, P.; Tanas, MZ.; Rubin, BP. (Aug 2014). "STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics.". Pathology 46 (5): 389-95. doi:10.1097/PAT.0000000000000122. PMID 24977739.
- ↑ Demicco, EG.; Harms, PW.; Patel, RM.; Smith, SC.; Ingram, D.; Torres, K.; Carskadon, SL.; Camelo-Piragua, S. et al. (May 2015). "Extensive survey of STAT6 expression in a large series of mesenchymal tumors.". Am J Clin Pathol 143 (5): 672-82. doi:10.1309/AJCPN25NJTOUNPNF. PMID 25873501.