Hyperplastic polyp with perineuromatous stroma
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| Hyperplastic polyp with perineuromatous stroma | |
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| Diagnosis in short | |
 Hyperplastic polyp with perineuromatous stroma. H&E stain. | |
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| Synonyms | benign serrated colorectal fibroblastic polyps/intramucosal perineurioma, hybrid hyperplastic polyp/mucosal perineurioma |
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| LM | serrated epithelial cells (at the surface), perineuromatous stroma |
| LM DDx | colonic ganglioneuroma, hyperplastic polyp |
| Site | colon and rectum |
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| Prevalence | rare |
| Endoscopy | polyp |
| Prognosis | benign |
| Clin. DDx | other types of colorectal polyps |
Hyperplastic polyp with perineuromatous stroma, also known as benign serrated colorectal fibroblastic polyps/intramucosal perineurioma and hybrid hyperplastic polyp/mucosal perineurioma, is a benign colorectal polyp.
General
- Rare.
- Benign.[1]
Microscopic
Features:
- Serrated epithelial cells (at the surface of the gland) - key feature.
- Serrated appearance = saw-tooth appearance, epithelium has jagged edge.
- Perineuromatous stroma.
DDx:
Images
HP with PNS - very low mag.
HP with PNS - low mag.
HP with PNS - intermed. mag.
HP with PNS - intermed. mag.
HP with PNS - high mag.
HP with PNS - high mag.
HP with PNS - very high mag.
See also
References
- ↑ Agaimy, A.; Stoehr, R.; Vieth, M.; Hartmann, A. (Nov 2010). "Benign serrated colorectal fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF mutations.". Am J Surg Pathol 34 (11): 1663-71. doi:10.1097/PAS.0b013e3181f4a458. PMID 20962618.