Serous borderline tumour

Serous borderline tumour is a Muellerian epithelial ovarian tumour with a behaviour that borders on malignant.

It is also known as serous ovarian tumour of low malignant potential.

General

• Usually benign.
• Require long term follow-up.

Microscopic

Features:

• Cuboidal to columnar epithelium with mild to moderate atypia.
• No invasive.
• "Sparse" mitoses.
• +/-Psammoma bodies.
• +/-Micropapillary architecture - often described as a medusa head pattern.

DDx:

• Serous carcinoma of the ovary - focus a with stromal invasion >5mm (linear measurement) or > 10 mm² (area).
  • Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).
• Clear cell carcinoma of the ovary - classically associated with endometriosis, have simpler, smaller papillae without branching.

Images:

• Serous ovarian LMP tumour (radiographics.rsna.org).

Subclassification

Typical subdivided into:

• Micropapillary serous borderline tumour.
• Typical serous borderline tumour (SBOT).

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Cyst and Right Fallopian Tube, Excision:
     - SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
     - Fallopian tube within normal limits.
     - NEGATIVE for evidence of invasion.

Comment:
The lesion appears to be confined to a cystic structure.

See also

• Ovarian tumours.