Acquired cystic disease-associated renal cell carcinoma
| Acquired cystic disease-associated renal cell carcinoma | |
|---|---|
| Diagnosis in short | |
 Acquired cystic disease-associated renal cell carcinoma with non-polarized light and polarized light to highlight the oxylate crystals. H&E stain. | |
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| LM | sieve-like architecture (tubular structures/cribriforming), oxylate crystals - seen best in polarized light |
| LM DDx | acquired cystic renal disease, papillary renal cell carcinoma, hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma |
| IHC | AMACR +ve, CD10 +ve, pankeratin +ve, CK7 +ve (heterogeneous), EMA -ve |
| Gross | kidney with cystic changes, thinned cortex |
| Grossing notes | total nephrectomy for tumour grossing, partial nephrectomy grossing |
| Staging | kidney cancer staging |
| Site | kidney - see kidney tumours |
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| |
| Associated Dx | end-stage renal disease |
| Prevalence | rare |
Acquired cystic disease-associated renal cell carcinoma, abbreviated ACD-RCC, is a rare kidney cancer that arises in the context of chronic renal failure.
General
- Arise in the context of long-standing end-stage renal disease (ESRD).[1]
Gross
- Cysts.
Microscopic
Features:
- Tubular structures with cribriforming/a sieve-like architecture.[2]
- Hobnail cells.
- Oxylate crystals - important.
- Look somewhat like cholesterol clefts.
DDx:
- Acquired cystic renal disease.
- Papillary renal cell carcinoma.
- Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma.
Images
Case
<gallery> Image: Acquired cystic disease-associated renal cell carcinoma -- very low mag.jpg | ACD-RCC - very low mag. Image: Acquired cystic disease-associated renal cell carcinoma -- low mag.jpg | ACD-RCC - low mag. Image: Acquired cystic disease-associated renal cell carcinoma -- intermed mag.jpg | ACD-RCC - intermed. mag. Image: Acquired cystic disease-associated renal cell carcinoma - alt -- intermed mag.jpg | ACD-RCC - intermed. mag. Image: Acquired cystic disease-associated renal cell carcinoma -- high mag.jpg | ACD-RCC - high mag. Image: Acquired cystic disease-associated renal cell carcinoma -- very high mag.jpg | ACD-RCC - very high mag.
Image: Acquired cystic disease-associated renal cell carcinoma -2-- low mag.jpg | ACD-RCC - low mag. Image: Acquired cystic disease-associated renal cell carcinoma -2-- intermed mag.jpg | ACD-RCC - intermed. mag. Image: Acquired cystic disease-associated renal cell carcinoma -2- polarized -- intermed mag.jpg | ACD-RCC - intermed. mag. Image: Acquired cystic disease-associated renal cell carcinoma -2-- high mag.jpg | ACD-RCC - high mag. Image: Acquired cystic disease-associated renal cell carcinoma -2- polarized -- high mag.jpg | ACD-RCC - high mag. Image: Acquired cystic disease-associated renal cell carcinoma -2-- very high mag.jpg | ACD-RCC - very high mag. Image: Acquired cystic disease-associated renal cell carcinoma -2- polarized -- very high mag.jpg | ACD-RCC - very high mag.
www
IHC
Features:[1]
- AMACR +ve.
- CD10 +ve.
- Pankeratin +ve.
- CK7 +ve (heterogeneous).
Others:[1]
See also
References
- ↑ 1.0 1.1 1.2 Ahn, S.; Kwon, GY.; Cho, YM.; Jun, SY.; Choi, C.; Kim, HJ.; Park, YW.; Park, WS. et al. (Mar 2013). "Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features.". Med Mol Morphol. doi:10.1007/s00795-013-0028-x. PMID 23471757.
- ↑ Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.
- ↑ 3.0 3.1 URL: https://www.auanet.org/education/modules/pathology/kidney-carcinomas/acquired-cystic.cfm. Accessed on: 13 May 2015.
- ↑ 4.0 4.1 4.2 4.3 Amin, Mahul B.; Eble, John; Grignon, David; Srigley, John. (2013). Urological Pathology (1st ed.). Wolters Kluwer. pp. 113. ISBN 978-0781782814.