Pilomyxoid astrocytoma
Pilomyxoid astrocytoma is a neuropathology tumour related to pilocytic astrocytoma.
General
Features:[1]
- A variant of pilocytic astrocytoma.
- Childhood or adolescence.
- ICD-O: 9425/3
Grading:
- Currently no WHO grade assigned.[5]
- From 2007-2016 the tumor was WHO Grade II by definition.[1] Grading was dropped until further studies clarify the true behaviour.
Gross
Features:[1]
- Classically - hypothalamic location/suprasellar location; may involve the sella turcica.[6]
- Solid.
- Well-circumscribed.
Microscopic
Features:[1]
- Consists of small round/ovoid bland cells in a myxoid stroma.
- Hair-like fibres ~ 1 micrometer.
- Often difficult to appreciate on standard (H&E) histologic sections.
- Usually angiocentric (surround blood vessel) - key feature.
Notes:[1]
- Rosenthal fibres are absent - key negative.
- Monophasic (unlike classical pilocytic astrocytomas) - key negative.
- May rarely have eosinophilic granular bodies.
Images
Pilomyxoid astrocytoma. (WC/Marvin 101)
Pilomyxoid astrocytoma. (WC)
Pilomyxoid astrocytoma - Alcian blue (WC)
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Perry, Arie; Brat, Daniel J. (2010). Practical Surgical Neuropathology: A Diagnostic Approach: A Volume in the Pattern Recognition series (1st ed.). Churchill Livingstone. pp. 86. ISBN 978-0443069826.
- ↑ Komotar RJ, Mocco J, Jones JE, et al. (June 2005). "Pilomyxoid astrocytoma: diagnosis, prognosis, and management". Neurosurg Focus 18 (6A): E7. PMID 16048293.
- ↑ Louis, DN.; Perry, A.; Reifenberger, G.; von Deimling, A.; Figarella-Branger, D.; Cavenee, WK.; Ohgaki, H.; Wiestler, OD. et al. (Jun 2016). "The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.". Acta Neuropathol 131 (6): 803-20. doi:10.1007/s00401-016-1545-1. PMID 27157931.
- ↑ Kleinschmidt-DeMasters, BK.; Donson, AM.; Vogel, H.; Foreman, NK. (Jul 2015). "Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA.". Brain Pathol 25 (4): 429-40. doi:10.1111/bpa.12239. PMID 25521223.
- ↑ Louis, DN.; Perry, A.; Reifenberger, G.; von Deimling, A.; Figarella-Branger, D.; Cavenee, WK.; Ohgaki, H.; Wiestler, OD. et al. (Jun 2016). "The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.". Acta Neuropathol 131 (6): 803-20. doi:10.1007/s00401-016-1545-1. PMID 27157931.
- ↑ Alimohamadi M, Bidabadi MS, Ayan Z, Ketabchi E, Amirjamshidi A (December 2009). "Pilomyxoid astrocytoma with involvement of the sella turcica in an adolescent". J Clin Neurosci 16 (12): 1648–9. doi:10.1016/j.jocn.2009.01.035. PMID 19766001.