Benign clear cell clusters of the kidney
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| Benign clear cell clusters of the kidney | |
|---|---|
| Diagnosis in short | |
 Benign clear cell clusters of the kidney. H&E stain. | |
|
| |
| LM | large cells in "small" nests with voluminous clear cytoplasm and small nuclei without prominent nucleoli |
| LM DDx | chromophobe renal cell carcinoma, other clear cell tumours |
| IHC | PAX8 +ve, CK7 +ve, AMACR -ve, CD68 -ve, CD10 +ve/-ve, CD117 +ve/-ve, vimentin -ve, CA9 -ve |
| Site | kidney - see kidney tumours |
|
| |
| Clinical history | chronic renal insufficiency |
| Prevalence | very rare |
| Radiology | +/-renal mass |
| Prognosis | presumed benign based on limited data/unknown |
Benign clear cell clusters of the kidney are a rare finding that may be confused for renal cell carcinoma[1] or may represent a precursor lesion of renal cell carcinoma.[2]
General
- Associated with chronic renal insufficiency.
Microscopic
Features:
- Large cells predominantly in "small" nests with:
- Voluminous clear cytoplasm.
- Small nuclei without prominent nucleoli (ISUP nucleolar grade 1 or 2).
Notes:
- Tubules with narrow lumens may be present.
- "Small" nests: typically less than 1.5 mm.
DDx:
IHC
Features:[1]
Others:[1]
- CA9 -ve.
- vimentin -ve.
- AMACR -ve.
- CD68 -ve.
- Alpha-inhibin -ve.
- Calretinin -ve.
- Melan A -ve.
- HMB-45 -ve.
Images
BCCC - very low mag. (WC)
BCCC - low mag. (WC)
BCCC - intermed. mag. (WC)
BCCC - intermed. mag. (WC)
BCCC - high mag. (WC)
BCCC - high mag. (WC)
BCCC - very high mag. (WC)
See also
References
- ↑ 1.0 1.1 1.2 "Clear cell clusters in the kidney: a rare finding that should not be misdiagnosed as renal cell carcinoma". Virchows Arch. January 2021. doi:10.1007/s00428-021-03018-4. PMID 33447899.
- ↑ Ross J, He H, Lin X, Yang X, "Clear cell cluster in the kidney: Is this a precursor lesion of renal cell carcinoma?", USCAP Annual Meeting 2018, Abstrct ID# 1058.