Benign lymphoepithelial lesion
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Benign lymphoepithelial lesion, also known as benign lymphoepithelial cyst, is a rare benign lesion of the head and neck.
It should not be confused the lymphoepithelial lesion found in the GI tract.
General
- Usually parotid gland.
- Associated with autoimmune disease, e.g. Sjoegren disease, may not remain benign.[1]
- May be seen in the context of HIV.[2]
Microscopic
Features:
- Lymphocytes.
- Ductal epithelial cells.[3]
Note:
- Must rule-out (MALT) lymphoma.
IHC
- CD20, CD3 -- mixed population.
- Kappa ~ lambda.
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Right Total Parotid Gland, Excision:
- Lymphoepithelial lesion/cyst, benign.
- Benign parotid gland.
- Two lymph nodes, NEGATIVE for malignancy (0/2).
Micro
The sections show a multiloculated cyst with thin walls containing bland lymphoid cells and unremarkable paucicellular fibrotic tissue. The lymphoid component has germinal centre formation. The cyst lining is predominantly a simple thin epithelium. Minimal cytoplasm is present in the cyst lining. Focally, the epithelium is multilayered; however, pseudo-bilayering is absent. No significant atypia is present. Proliferative activity is not apparent.
See also
References
- ↑ Goto, TK.; Shimizu, M.; Kobayashi, I.; Chikui, T.; Kanda, S.; Toshitani, K.; Shiratsuchi, Y.; Yoshida, K. (May 2002). "Lymphoepithelial lesion of the parotid gland.". Dentomaxillofac Radiol 31 (3): 198-203. doi:10.1038/sj/dmfr/4600690. PMID 12058269.
- ↑ "HIV-associated benign lymphoepithelial cysts of the parotid glands confirmed by HIV-1 p24 antigen immunostaining". BMJ Case Rep 2017. September 2017. doi:10.1136/bcr-2017-221869. PMC 5652621. PMID 28963391. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652621/.
- ↑ Metwaly, H.; Cheng, J.; Ida-Yonemochi, H.; Ohshiro, K.; Jen, KY.; Liu, AR.; Saku, T. (Jul 2003). "Vascular endothelial cell participation in formation of lymphoepithelial lesions (epi-myoepithelial islands) in lymphoepithelial sialadenitis (benign lymphoepithelial lesion).". Virchows Arch 443 (1): 17-27. doi:10.1007/s00428-003-0824-0. PMID 12761623.