The seminal vesicles, abbreviated SV, are a pair of organs closely associated with the prostate gland that add fluid to the ejaculate. They are seen attached to radical prostatectomy specimens.

Normal seminal vesicles

General

Seen in radical prostatectomies and occasionally in core biopsies.
Very rarely a site of a primary cancer.

Gross

Worm-like paired organs.
Empty into the ejaculatory ducts (as does the vas deferens).

Relationship between the SVs, ejaculatory ducts and vas deferens.
Relationship between the SVs, prostate and bladder.

Microscopic

Fern-like architecture - epithelial component clustered closely, looks like it connects.
- Epithelium surrounded by a thick layer of muscle (>10 cells across ~80 microns).
Lipofuscin (coarse cytoplasmic yellow granules approximately 1-2 micrometers) - key feature.
Nucleoli - common.
Nuclear inclusions - common.^[1]

Notes:

The ejaculatory ducts have the same epithelium as the seminal vesicles.^[2]

Images

SV - showing fern-like architecture. (WC/Nephron)
SV - looking vaguely like to prostate adenocarcinoma. (WC/Nephron)
SV - looks a bit like prostate but lumina too big. (WC/Nephron)

www:

SV (udel.edu).

IHC

PSA -ve.^[3]
CK7 +ve.^[4]^[5]
CK20 -ve.^[4]
p63 +ve.^[5]
CK34betaE12 -ve.^[5]
AMACR -ve.^[5]

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B. PROSTATE, RIGHT MEDIAL SUPERIOR, BIOPSY:
- BENIGN PROSTATE TISSUE.
- BENIGN SEMINAL VESICLE/EJACULATORY DUCT.

Pathology

Primary seminal vesicle carcinoma

Main article: Primary seminal vesicle carcinoma

Amyloid in the seminal vesicles

Main article: Amyloid in the seminal vesicles

Benign

Stromal lipofuscinosis of the seminal vesicle

Main article: Stromal lipofuscinosis of the seminal vesicle

References

↑ URL: http://surgpathcriteria.stanford.edu/prostate/adenocarcinoma/benign-vs-carcinoma.html. Accessed on: 10 January 2013.
↑ Leroy X, Ballereau C, Villers A, et al. (April 2003). "MUC6 is a marker of seminal vesicle-ejaculatory duct epithelium and is useful for the differential diagnosis with prostate adenocarcinoma". Am. J. Surg. Pathol. 27 (4): 519–21. PMID 12657938.
↑ Itami, Y.; Nagai, Y.; Kobayashi, Y.; Shimizu, N.; Yamamoto, Y.; Minami, T.; Hayashi, T.; Nozawa, M. et al. (Jul 2012). "[A case of prostatic cancer with a low PSA level accompanied with cystic formation requiring differentiation from adenocarcinoma of the seminal vesicle].". Hinyokika Kiyo 58 (7): 349-53. PMID 22895132.
↑ ^4.0 ^4.1 Tarján, M.; Ottlecz, I.; Tot, T. (Jan 2009). "Primary adenocarcinoma of the seminal vesicle.". Indian J Urol 25 (1): 143-5. doi:10.4103/0970-1591.45557. PMID 19468449.
↑ ^5.0 ^5.1 ^5.2 ^5.3 Terada, T. (2011). "Monstrous epithelial cell clusters in the seminal vesicle.". Int J Clin Exp Pathol 4 (7): 727-30. PMID 22076175.

[1] URL: http://surgpathcriteria.stanford.edu/prostate/adenocarcinoma/benign-vs-carcinoma.html. Accessed on: 10 January 2013.

[pmid12657938-2] Leroy X, Ballereau C, Villers A, et al. (April 2003). "MUC6 is a marker of seminal vesicle-ejaculatory duct epithelium and is useful for the differential diagnosis with prostate adenocarcinoma". Am. J. Surg. Pathol. 27 (4): 519–21. PMID 12657938.

[pmid22895132-3] Itami, Y.; Nagai, Y.; Kobayashi, Y.; Shimizu, N.; Yamamoto, Y.; Minami, T.; Hayashi, T.; Nozawa, M. et al. (Jul 2012). "[A case of prostatic cancer with a low PSA level accompanied with cystic formation requiring differentiation from adenocarcinoma of the seminal vesicle].". Hinyokika Kiyo 58 (7): 349-53. PMID 22895132.

[pmid19468449-4] 4.0 ^4.1 Tarján, M.; Ottlecz, I.; Tot, T. (Jan 2009). "Primary adenocarcinoma of the seminal vesicle.". Indian J Urol 25 (1): 143-5. doi:10.4103/0970-1591.45557. PMID 19468449.

[pmid22076175-5] 5.0 ^5.1 ^5.2 ^5.3 Terada, T. (2011). "Monstrous epithelial cell clusters in the seminal vesicle.". Int J Clin Exp Pathol 4 (7): 727-30. PMID 22076175.

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Seminal vesicles

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