Cytogenetic tests
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Thsi article is a list of common cytogenetic tests. An introduction to cytogenetics is in the cytogenetics article.
Karyotyping
Findings:
- 5q deletion seen in myelodysplastic syndromes.[1]
ISH
Cytogenetic tests at one hospital:[2]
| Test | Parameters | Notes |
|---|---|---|
| BCR/ABL1 | CML or ALL | Tx (imatinib) |
| MLL | ALL or AML | ? |
| MYC | Burkitt's lymphoma + others | prognostic |
| ALK | DLBCL - BCL6, BCL2 or MYC | ? |
| MALT1 | MALT lymphoma | trisomy 3, trisomy 18 |
| CCND1 | mantle cell lymphoma | ? |
| BCL2 | follicular lymphoma | |
| ERBB2 (HER2) | breast cancer | prognostic, Tx (trastuzumab) |
| EWSR1 | small round blue cell tumour (suspected Ewing sarcoma) |
See also
References
- ↑ Nimer, SD. (Jun 2006). "Clinical management of myelodysplastic syndromes with interstitial deletion of chromosome 5q.". J Clin Oncol 24 (16): 2576-82. doi:10.1200/JCO.2005.03.6715. PMID 16735711.
- ↑ Kamel-Reid, Suzanne. University Health Network / Department of Pathology. Cancer Cytogenetics & Molecular Diagnostics Laboratories. Test Requisition. August 2010.