NUT carcinoma
Jump to navigation
Jump to search
NUT midline carcinoma, abbreviated NMC, is a super rare tumour of the head and neck.
General
- Not specific to any tissue type or organ.[1]
- Defined by mutation in NUT gene.
- NUT = Nuclear protein in testis.[2]
Clinical:
- Usually midline - as the name of the tumour suggests.
- Case report of a NMC in the parotid gland.[3]
- Head, neck and mediastinum.[4]
- Very poor prognosis.[3]
Microscopic
- Poorly differentiated carcinoma.
- Cohesive malignant cells.
- Islands of well-differentiated squamous epithelium - key feature.
DDx:
- Carcinoma ex pleomorphic adenoma.
- Poorly differentiated carcinoma.
Molecular
- Rearrangement of the NUT gene.[1]
See also
References
- ↑ 1.0 1.1 1.2 French, CA. (Nov 2010). "NUT midline carcinoma.". Cancer Genet Cytogenet 203 (1): 16-20. doi:10.1016/j.cancergencyto.2010.06.007. PMID 20951314.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608963
- ↑ 3.0 3.1 den Bakker, MA.; Beverloo, BH.; van den Heuvel-Eibrink, MM.; Meeuwis, CA.; Tan, LM.; Johnson, LA.; French, CA.; van Leenders, GJ. (Aug 2009). "NUT midline carcinoma of the parotid gland with mesenchymal differentiation.". Am J Surg Pathol 33 (8): 1253-8. doi:10.1097/PAS.0b013e3181abe120. PMID 19561446.
- ↑ 4.0 4.1 4.2 French, CA. (Jun 2010). "Demystified molecular pathology of NUT midline carcinomas.". J Clin Pathol 63 (6): 492-6. doi:10.1136/jcp.2007.052902. PMID 18552174.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608749